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	MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists.
	Lv C1; Li FY1; Sheng XL1; Song YL1; Meng QY1; Yuan SK3; Luan LM4; Andl T4; Li X1; Feng X4; Jiao BW5; Xu MG6; Plikus MV7; Dai X6; Lengner C9,10,11; Cui W1,12; Ren FZ1; Shuai JW13; Tian YH1; Yu ZY*1; zyu@cau.edu.cn
	2017
发表期刊	NATURE COMMUNICATIONS
卷号	8期号:X页码:e1036
摘要	MicroRNA-mediated post-transcriptional regulation plays key roles in stem cell self-renewal and tumorigenesis. However, the in vivo functions of specific microRNAs in controlling mammary stem cell (MaSC) activity and breast cancer formation remain poorly understood. Here we show that miR-31 is highly expressed in MaSC-enriched mammary basal cell population and in mammary tumors, and is regulated by NF-κB signaling. We demonstrate that miR-31 promotes mammary epithelial proliferation and MaSC expansion at the expense of differentiation in vivo. Loss of miR-31 compromises mammary tumor growth, reduces the number of cancer stem cells, as well as decreases tumor-initiating ability and metastasis to the lung, supporting its pro-oncogenic function. MiR-31 modulates multiple signaling pathways, including Prlr/Stat5, TGFβ and Wnt/β-catenin. Particularly, it activates Wnt/β-catenin signaling by directly targeting Wnt antagonists, including Dkk1. Importantly, Dkk1 overexpression partially rescues miR31-induced mammary defects. Together, these findings identify miR-31 as the key regulator of MaSC activity and breast tumorigenesis.
资助者	Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029).
收录类别	SCI
语种	英语
资助者	Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029). ; Z.Y. is supported by the National Natural Science Foundation of China (No. 81572614,31271584); Beijing Nature Foundation Grant (5162018); the Major Project for Cultiva tion Technology (2016ZX08008001, 2014ZX08008001); National Dairy Industry and Technology System (No.CARS-36); Basic Research Program (2015QC0104, 2015TC041, 2016SY001, 2016QC086); SKLB Open Grant (2015SKLB6-16). M.V.P. is supported by the NIH NIAMS grants R01-AR067273, R01-AR069653. J.S. is supported by the National Natural Science Foundation of China (No. 31370830 and 11675134) and the 111 Project (No. B16029).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12082
专题	遗传资源与进化国家重点实验室 科研部门_发育的印迹调控与进化学（焦保卫）
通讯作者	zyu@cau.edu.cn
作者单位	1.State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. 2.Department of Biochemistry and Molecular Biology, Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, 050200, China. 3.Department of Biochemistry and Molecular Biology, Basic Medical College, Tianjin Medical University, Tianjin, 300070, China. 4.Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, London, W12 0NN, UK. 5.Department of Physics and State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, Xiamen University, Xiamen, 361005, China 6.Vanderbilt University Medical Center, Nashville, TN, 37232, USA. 7.State Key Laboratory of Genetic Resources and Evolution of Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China 8.Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. 9.Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research, Center for Complex Biological Systems, University of California, Irvine, CA, 92697, USA. 10.Departments of Biological Chemistry and Dermatology, School of Medicine, University of California, Irvine, CA, 92697, USA. 11.Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. 12.Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA 13.Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
推荐引用方式 GB/T 7714	Lv C,Li FY,Sheng XL,et al. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists.[J]. NATURE COMMUNICATIONS,2017,8(X):e1036.
APA	Lv C.,Li FY.,Sheng XL.,Song YL.,Meng QY.,...&zyu@cau.edu.cn.(2017).MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists..NATURE COMMUNICATIONS,8(X),e1036.
MLA	Lv C,et al."MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists.".NATURE COMMUNICATIONS 8.X(2017):e1036.

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