A membrane disrupting toxin from wasp venom underlies the molecular mechanism of tissue damage

doi:10.1016/j.toxicon.2018.04.011

	A membrane disrupting toxin from wasp venom underlies the molecular mechanism of tissue damage
	Rose Ombati ; Yunfei Wang ; Shilong Yang; Ren Lai; Canwei Du ; Xiancui Lu ; Bowen Li ; Atunga Nyachieo ; Yaxiong Li*; liyaxiong62@aliyun.com
	2018
发表期刊	Toxicon
期号	48 页码:56-63
摘要	The molecular mechanism of the local hypersensitivity reactions to wasp venom including dermal necrosis remains an enigma regardless of the numerosity of the reported cases. In this study, we discovered a new membrane disrupting toxin, VESCP-M2 responsible for tissue damage symptoms following Vespa mandarinia envenomation. Electrophysiological assays revealed a potent ability of VESCP-M2 to permeate the cell membrane whereas in vivo experiments demonstrated that VESCP-M2 induces edema, pain and dermal necrosis characterized by the presence of morphological and behavioral phenotypes, pro-inflammatory mediators, biomarkers as well as the disruption of dermal tissue. This study presents the molecular mechanism and symptom-related function of VESCP-M2 which may form a basis for prognosis as well as therapeutic interventions.
关键词	Wasp Envenomation Membrane Disrupting Toxin Inflammation Edema Tissue Necrosis
DOI	10.1016/j.toxicon.2018.04.011
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12133
专题	科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	liyaxiong62@aliyun.com
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 2.University of Chinese Academy of Sciences, Beijing 100049, China 3.College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 4.Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya PO Box 24481-00502, Karen, Nairobi, Kenya 5.Cardiovascular Surgery Department of Kunming Yan'an Hospital, Kunming 650051, China
推荐引用方式 GB/T 7714	Rose Ombati,Yunfei Wang,Shilong Yang*,et al. A membrane disrupting toxin from wasp venom underlies the molecular mechanism of tissue damage[J]. Toxicon,2018(48):56-63.
APA	Rose Ombati.,Yunfei Wang.,Shilong Yang.,Ren Lai.,Canwei Du.,...&liyaxiong62@aliyun.com.(2018).A membrane disrupting toxin from wasp venom underlies the molecular mechanism of tissue damage.Toxicon(48),56-63.
MLA	Rose Ombati,et al."A membrane disrupting toxin from wasp venom underlies the molecular mechanism of tissue damage".Toxicon .48(2018):56-63.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
120.pdf（1388KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文