Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor

doi:10.1038/s41590-018-0063-9

	Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor
	Lin Jin 1,2,9; Xiaopeng Qi 1; Chuanbin Shen 1,9; Ren Lai 1,2; Xue Hao 1,9; Peng Sun 3,9; Pengpeng Li 1,4; Tao Xu 1; Chunmiao Hu 1 , Ombati Rose 1,5; Hongning Zhou 6; Mingdong Yang 6; Cheng-Feng Qin 7; Jingya Guo 8; Hua Peng 8; Mingzhao Zhu 8; Gong Cheng 3
	2018
发表期刊	Nature Immunology
期号	19 页码:342–353
摘要	Pathogens have co-evolved with mosquitoes to optimize transmission to hosts. Mosquito salivary-gland extract is knownto modulate host immune responses and facilitate pathogen transmission, but the underlying molecular mechanisms of thishave remained unknown. In this study, we identified and characterized a prominent 15-kilodalton protein, LTRIN, obtainedfrom the salivary glands of the mosquito Aedes aegypti. LTRIN expression was upregulated in blood-fed mosquitoes, and LTRINfacilitated the transmission of Zika virus (ZIKV) and exacerbated its pathogenicity by interfering with signaling through thelymphotoxin-β receptor (LTβ R). Mechanically, LTRIN bound to LTβ R and ‘preferentially’ inhibited signaling via the transcrip-tion factor NF-κ B and the production of inflammatory cytokines by interfering with the dimerization of LTβ R during infectionwith ZIKV. Furthermore, treatment with antibody to LTRIN inhibited mosquito-mediated infection with ZIKV, and abolishingLTβ R potentiated the infectivity of ZIKV both in vitro and in vivo. This study provides deeper insight into the transmission ofmosquito-borne diseases in nature and supports the therapeutic potential of inhibiting the action of LTRIN to disrupt ZIKVtransmission.
DOI	10.1038/s41590-018-0063-9
语种	英语
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12263
专题	科研部门_病原菌感染与宿主免疫机制（齐晓朋）
通讯作者	Mingzhao Zhu; Gong Cheng
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. 2.Sino-Africa Joint Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. 3.Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China. 4.College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, China. 5.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China. 6.Yunnan Institute of Parasitic Diseases, Pu’er, Yunnan, China. 7.Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. 8.Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. 9.These authors contributed equally: Lin Jin, Xiaomin Guo, Chuanbin Shen, Xue Hao and Peng Sun.
推荐引用方式 GB/T 7714	Lin Jin,Xiaopeng Qi,Chuanbin Shen,et al. Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor[J]. Nature Immunology,2018(19):342–353.
APA	Lin Jin.,Xiaopeng Qi.,Chuanbin Shen.,Ren Lai.,Xue Hao.,...&Gong Cheng.(2018).Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor.Nature Immunology(19),342–353.
MLA	Lin Jin,et al."Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor".Nature Immunology .19(2018):342–353.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
58.pdf（3664KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文