| Antitumor aporphine alkaloids from Thalictrum wangii | |
| Qiong Jin1,3; Xiao-Dong Luo1,3; Afsar Khan5; Dong Yang2,4; Bei Wang3,4; Xin Wei3,4; Ying Sun6; Yun-Li Zhao3; Yi-Fen Wang3; Ya-Ping Liu3; Xu-Dong Zhao2 | |
| 2018 | |
| 发表期刊 | Fitoterapia
 |
| 期号 | 128页码:204–212 |
| 摘要 | Nine new isoquinoline alkaloids, including two proaporphine (1–2), three aporphine (3–5), two oxoaporphine(6–7), and two seco-bisbenzylisoquinoline (8–9), together with three known alkaloids (10−12) were isolatedfrom the whole plant of Thalictrum wangii. Their structures were established on the basis of spectroscopic data.The antitumor activities of the isolated compounds were evaluated in vitro against glioma stem cells. Compounds3–8 showed the cytotoxicity with IC 50 values 15–20 μg/mL. |
| 关键词 | Thalictrum Wangii Aporphine Alkaloids Antitumor Glioma Stem Cells |
| DOI | 10.1016/j.fitote.2018.05.012 |
| 语种 | 英语 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/12264 |
| 专题 | 科研部门_肿瘤干细胞生物学（赵旭东） |
| 通讯作者 | Ya-Ping Liu; Xu-Dong Zhao |
| 作者单位 | 1.Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, PR China 3.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences/Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, PR China 4.University of Chinese Academy of Sciences, Beijing 100049, PR China 5.Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan 6.School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China |
| 推荐引用方式 GB/T 7714 | Qiong Jin,Xiao-Dong Luo,Afsar Khan,et al. Antitumor aporphine alkaloids from Thalictrum wangii[J]. Fitoterapia,2018(128):204–212. |
| APA | Qiong Jin.,Xiao-Dong Luo.,Afsar Khan.,Dong Yang.,Bei Wang.,...&Xu-Dong Zhao.(2018).Antitumor aporphine alkaloids from Thalictrum wangii.Fitoterapia(128),204–212. |
| MLA | Qiong Jin,et al."Antitumor aporphine alkaloids from Thalictrum wangii".Fitoterapia .128(2018):204–212. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 59.pdf（1666KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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