Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours.

doi:10.1038/s41559-018-0611-6

	Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours.
	Anna V. Kukekova 1; Jennifer L. Johnson 1; Xueyan Xiang 2; Shaohong Feng 2; Shiping Liu 2; Halie M. Rando 1; Anastasiya V. Kharlamova 3; Yury Herbeck 3; Natalya A. Serdyukova 4; Zijun XiongZijun Xiong 2,5; Violetta Beklemischeva 4; Klaus-Peter Koepfli 6,7; Rimma G. Gulevich 3; Anastasiya V. Vladimirova 3; Jessica P. Hekman 1,13; Polina L. Perelman 4,8; Aleksander S. Graphodatsky 4,8; Stephen J. O’Brien 8,9; Xu Wang 10,14; Andrew G. Clark 10; Gregory M. Acland 11; Lyudmila N. Trut 3; Guojie Zhang 2,5,12
	2018
发表期刊	Nature Ecology & Evolution
期号	页码:
摘要	Strains of red fox (Vulpes vulpes) with markedly different behavioural phenotypes have been developed in the famous long-term selective breeding programme known as the Russian farm-fox experiment. Here we sequenced and assembled the red fox genome and re-sequenced a subset of foxes from the tame, aggressive and conventional farm-bred populations to identify genomic regions associated with the response to selection for behaviour. Analysis of the re-sequenced genomes identified 103 regions with either significantly decreased heterozygosity in one of the three populations or increased divergence between the populations. A strong positional candidate gene for tame behaviour was highlighted: SorCS1, which encodes the main trafficking protein for AMPA glutamate receptors and neurexins and suggests a role for synaptic plasticity in fox domestication. Other regions identified as likely to have been under selection in foxes include genes implicated in human neurological disorders, mouse behaviour and dog domestication. The fox represents a powerful model for the genetic analysis of affiliative and aggressive behaviours that can benefit genetic studies of behaviour in dogs and other mammals, including humans.
DOI	10.1038/s41559-018-0611-6
语种	英语
引用统计	被引频次：40[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12281
专题	科研部门_遗传多样性基因组学研究组（张国捷）
通讯作者	Anna V. Kukekova; Guojie Zhang
作者单位	1.Animal Sciences Department, College of ACES, University of Illinois at Urbana, Champaign, IL, USA. 2.China National Genebank, BGI -Shenzhen, Shenzhen, China. 3.Institute of Cytology and Genetics of the Russian Academy of Sciences, Novosibirsk, Russia. 4.Section for Ecology and Evolution, Department of Biology, University of Copenhagen, Copenhagen, Denmark 5.Present address: The Broad Institute of MIT and Harvard, Cambridge, MA, USA. 6.Present address: Department of Pathobiology, Auburn University, Auburn, AL, USA. 7.Institute of Molecular and Cell Biology of the Russian Academy of Sciences, Novosibirsk, Russia. 8.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China. 9.Smithsonian Conservation Biology Institute, National Zoological Park, Washington DC, USA. 10.Theodosius Dobzhansky Center for Genome Bioinformatics, Saint Petersburg State University, Saint Petersburg, Russia. 11.Novosibirsk State University, Novosibirsk, Russia. 12.Guy Harvey Oceanographic Center, Halmos College of Natural Sciences and Oceanography, Nova Southeastern University, Fort Lauderdale, FL, USA. 13.Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA. 14.Baker Institute for Animal Health, Cornell University, College of Veterinary Medicine, Ithaca, NY, USA.
推荐引用方式 GB/T 7714	Anna V. Kukekova,Jennifer L. Johnson,Xueyan Xiang,et al. Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours.[J]. Nature Ecology & Evolution,2018():.
APA	Anna V. Kukekova.,Jennifer L. Johnson.,Xueyan Xiang.,Shaohong Feng.,Shiping Liu.,...&Guojie Zhang.(2018).Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours..Nature Ecology & Evolution(),.
MLA	Anna V. Kukekova,et al."Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours.".Nature Ecology & Evolution .(2018):.

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