Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis

doi:10.1038/s41388-017-0089-8

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis
	Huichun Liang 1,2; Ceshi Chen 1; Zhongmei Zhou 1; Jiao Wu 4; Fei Ge 5; Zongcheng Li 6; Hailin Zhang 1; Jian Sun 3; Fubing Li 1,2; Rong Liu 1
	2018
发表期刊	Oncogene
期号	37 页码:1961–1975
摘要	It is well documented that hypoxia activates the hypoxia-inducible factor 1-alpha (HIF1α)/vascular endothelial growth factorA (VEGFA) axis to promote angiogenesis in breast cancer. However, it is unclear how this axis is negatively regulated. Inthis study, we demonstrated that miR-153 directly inhibits expression of HIF1α by binding to the 3′UTR of HIF1A mRNA,as well as suppresses tube formation of primary human umbilical vein endothelial cells (HUVECs) and breast cancerangiogenesis by decreasing the secretion of VEGFA. Importantly, expression of miR-153 was induced by hypoxia-stimulated ER stress, which activates IRE1α and its downstream transcription factor X-box binding protein 1 (XBP1). X-boxbinding protein 1 directly binds to the promoter of the miR-153 host gene PTPRN and activates transcription. These resultsindicate that hypoxia induces miR-153 to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis and miR-153 couldbe used for breast cancer anti-angiogenesis therapy.
DOI	10.1038/s41388-017-0089-8
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12294
专题	科研部门_肿瘤生物学（陈策实）
通讯作者	Rong Liu
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.University of the Chinese Academy of Sciences, Beijing, China 3.Medical Faculty of Kunming University of Science and Technology, Kunming, China 4.Department of the Second Medical Oncology, The 3rd Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 5.Department of the Breast Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 6.State Key Laboratory of Proteomics, Translational Medicine Center of Stem Cells, 307-lvy Translational Medicine Center, Laboratory of Oncology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing, China
推荐引用方式 GB/T 7714	Huichun Liang,Ceshi Chen,Zhongmei Zhou,et al. Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis[J]. Oncogene,2018(37):1961–1975.
APA	Huichun Liang.,Ceshi Chen.,Zhongmei Zhou.,Jiao Wu.,Fei Ge.,...&Rong Liu.(2018).Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis.Oncogene(37),1961–1975.
MLA	Huichun Liang,et al."Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis".Oncogene .37(2018):1961–1975.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
83.pdf（6540KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文