LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci

doi:10.1038/s41419-018-0869-2

	LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci
	Shaowei Wang 1,2; Chunlian Wu 1; Honglei Zhang 2; Baowei Jiao 2,7; Yujie Ma 2,3; Lei Ao 4; Li Zou 2; Qin Yang 2; Hao Zhu 5; Jianyun Nie 6
	2018
发表期刊	Cell Death & Disease
期号	9 页码:805
摘要	Triple-negative breast cancer (TNBC) exhibits poor prognosis, with high metastasis and low survival. Long non-codingRNAs (lncRNAs) play critical roles in tumor progression. Here, we identified lncRNA MIR100HG as a pro-oncogene forTNBC progression. Knockdown of MIR100HG decreased cell proliferation and induced cell arrest in the G1 phase,whereas overexpression of MIR100HG significantly increased cell proliferation. Furthermore, MIR100HG regulated thep27 gene to control the cell cycle, and subsequently impacted the progression of TNBC. In analyzing its underlyingmechanism, bioinformatics prediction and experimental data demonstrated that MIR100HG participated in theformation of RNA–DNA triplex structures. MIR100HG in The Cancer Genome Atlas (TCGA) and breast cancer cell linesshowed higher expression in TNBC than in other tumor types with poor prognosis. In conclusion, our data indicated anovel working pattern of lncRNA in TNBC progression, which may be a potential therapeutic target in such cancers.
DOI	10.1038/s41419-018-0869-2
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12349
专题	科研部门_发育的印迹调控与进化学（焦保卫）
通讯作者	Hao Zhu; Jianyun Nie
作者单位	1.Key Laboratory of Southwest China Wildlife Resources Conservation, China West Normal University, Ministry of Education, Nanchong 637009, China. 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China. 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650223, China. 4.Kunming Angel Women’s and Children’s Hospital, Kunming 650032, China. 5.Bioinformatics Section, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China 6.Department of Breast Cancer, Yunnan Cancer Center, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China. 7.Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Shaowei Wang,Chunlian Wu,Honglei Zhang,et al. LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci[J]. Cell Death & Disease,2018(9):805.
APA	Shaowei Wang.,Chunlian Wu.,Honglei Zhang.,Baowei Jiao.,Yujie Ma.,...&Jianyun Nie.(2018).LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci.Cell Death & Disease(9),805.
MLA	Shaowei Wang,et al."LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci".Cell Death & Disease .9(2018):805.

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