Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells

doi:10.1016/j.bmc.2018.02.024

	Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells
	Xin Wei ; Xu-Dong Zhao ; Jing Yang ; Xiao-Dong Luo ; Afsar Khan ; Hao-Fei Yu ; Yun-Li Zhao ; Yi-Fen Wang ; Ya-Ping Liu ; Zi-Feng Yang ; Wan-Yi Huang ; Xin-Hua Wang
	2018
发表期刊	Bioorganic & Medicinal Chemistry
期号	26 页码:1776–1783
摘要	Unlike reported bisindoles linked by single bond directly, alstoniasidines A (1) and B (2), from Alstoniascholaris featuring unprecedented skeleton with two indole moieties bridged by a sugar, represented anovel bisindole type having strictosamide-glucopyranose-picraline scaffold. Both compounds exhibitedselective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsicapoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF- a ), and thecleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. Thisfinding might provide new type of leads for the selective killing of human glioma stem cells.
关键词	Alstoniasidines a And b Sugar Bridged Bisindole Glioma Stem Cells Alstonia Scholaris
DOI	10.1016/j.bmc.2018.02.024
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12351
专题	科研部门_肿瘤干细胞生物学（赵旭东）
通讯作者	Wan-Yi Huang; Xin-Hua Wang
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, People’s Republic of China 3.Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan 4.University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China 5.Guangzhou Medical University, Guangzhou 511436, People’s Republic of China
推荐引用方式 GB/T 7714	Xin Wei,Xu-Dong Zhao,Jing Yang,et al. Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells[J]. Bioorganic & Medicinal Chemistry,2018(26):1776–1783.
APA	Xin Wei.,Xu-Dong Zhao.,Jing Yang.,Xiao-Dong Luo.,Afsar Khan.,...&Xin-Hua Wang.(2018).Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells.Bioorganic & Medicinal Chemistry(26),1776–1783.
MLA	Xin Wei,et al."Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells".Bioorganic & Medicinal Chemistry .26(2018):1776–1783.

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