KMS KUNMING INSTITUTE OF ZOOLOGY.CAS
| Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes | |
Cui-Ping Yang1; Xiong-Jian Luo1,6; Yong Wu1; Qiushuo Shen1; Yong Zeng2; Qiuxia Xiong2; Mengping Wei3; Chunhui Chen4; Jiewei Liu1; Yongxia Huo1; Kaiqin Li1; Gui Xue4; Yong-Gang Yao1,5 ; Chen Zhang3; Ming Li1,5; Yongbin Chen1,6
| |
| 2018 | |
| 发表期刊 | NATURE COMMUNICATIONS
 |
| 期号 | 9页码:838 |
| 摘要 | Recent genome-wide association studies (GWAS) have identified multiple risk loci that showstrong associations with schizophrenia. However, pinpointing the potential causal genes atthe reported loci remains a major challenge. Here we identify candidate causal genes forschizophrenia using an integrative genomic approach. Sherlock integrative analysis shows thatALMS1, GLT8D1, and CSNK2B are schizophrenia risk genes, which are validated using inde-pendent brain expression quantitative trait loci (eQTL) data and integrative analysis method(SMR). Consistently, gene expression analysis in schizophrenia cases and controls furthersupports the potential role of these three genes in the pathogenesis of schizophrenia. Finally,we show that GLT8D1 and CSNK2B knockdown promote the proliferation and inhibit thedifferentiation abilities of neural stem cells, and alter morphology and synaptic transmissionof neurons. These convergent lines of evidence suggest that the ALMS1, CSNK2B, and GLT8D1genes may be involved in pathophysiology of schizophrenia. |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/12370 |
| 专题 | 科研部门_肿瘤信号转导（陈勇彬） 科研部门_神经系统疾病（罗雄剑） |
| 通讯作者 | Yongbin Chen |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China. 2.Department of Psychiatry, The First Affiliated Hospital ofKunming Medical College, Kunming, Yunnan 650031, China. 3.State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences, Peking University, Beijing 100871, China. 4.State Key Laboratory of Cognitive Neuroscience and Learning, and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China 5.CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China 6.Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnna 650223, China |
| 推荐引用方式 GB/T 7714 | Cui-Ping Yang,Xiong-Jian Luo,Yong Wu,et al. Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes[J]. NATURE COMMUNICATIONS,2018(9):838. |
| APA | Cui-Ping Yang.,Xiong-Jian Luo.,Yong Wu.,Qiushuo Shen.,Yong Zeng.,...&Yongbin Chen.(2018).Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes.NATURE COMMUNICATIONS(9),838. |
| MLA | Cui-Ping Yang,et al."Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes".NATURE COMMUNICATIONS .9(2018):838. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 183.pdf（3180KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论