| Molecular basis for heat desensitization of TRPV1 ion channels |
| Luo, L; Wang, YF; Li, BW; Xu, LZ; Kamau, PM; Zheng, J; Yang, F; Yang, SL; Lai, R
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| 2019
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| 发表期刊 | NATURE COMMUNICATIONS
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| ISSN | 2041-1723
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| 卷号 | 10 |
| 摘要 | The transient receptor potential vanilloid 1 (TRPV1) ion channel is a prototypical molecular sensor for noxious heat in mammals. Its role in sustained heat response remains poorly understood, because rapid heat-induced desensitization (Dh) follows tightly heat-induced activation (Ah). To understand the physiological role and structural basis of Dh, we carried out a comparative study of TRPV1 channels in mouse (mV1) and those in platypus (pV1), which naturally lacks Dh. Here we show that a temperature-sensitive interaction between the N- and C-terminal domains of mV1 but not pV1 drives a conformational rearrangement in the pore leading to Dh. We further show that knock-in mice expressing pV1 sensed heat normally but suffered scald damages in a hot environment. Our findings suggest that Dh evolved late during evolution as a protective mechanism and a delicate balance between Ah and Dh is crucial for mammals to sense and respond to noxious heat. |
| 收录类别 | SCIE
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/12446
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| 专题 | 科研部门_天然药物功能蛋白质学科组（赖仞）
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推荐引用方式
GB/T 7714 |
Luo, L,Wang, YF,Li, BW,et al. Molecular basis for heat desensitization of TRPV1 ion channels[J]. NATURE COMMUNICATIONS,2019,10.
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| APA |
Luo, L.,Wang, YF.,Li, BW.,Xu, LZ.,Kamau, PM.,...&Lai, R.(2019).Molecular basis for heat desensitization of TRPV1 ion channels.NATURE COMMUNICATIONS,10.
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| MLA |
Luo, L,et al."Molecular basis for heat desensitization of TRPV1 ion channels".NATURE COMMUNICATIONS 10(2019).
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