| The defensive system of tree frog skin identified by peptidomics and RNA sequencing analysis |
| Rong, MQ; Liu, J; Liao, Q; Lin, ZL; Wen, B; Ren, Y; Lai, R
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| 2019
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| 发表期刊 | AMINO ACIDS
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| ISSN | 0939-4451
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| 卷号 | 51期号:2页码:345-353 |
| 摘要 | The diversity of defensive peptides from skin of amphibians has been demonstrated. These peptides may have resulted from the diversity of microorganisms encountered by amphibians. In this study, peptidomics and RNA sequencing analyses were used to study deeply the defensive peptides of the skin secretions from Polypedates megacephalus. A total of 99 defensive peptides have been identified from the skin secretions. Among these peptides, 3 peptides were myotropical peptides and 34 peptides classified as protease inhibitor peptides. 5 lectins, 8 antimicrobial peptides, 26 immunomodulatory peptides, 10 wound-healing peptides and 13 other bioactive peptides were identified as belonging to the innate immune system. One antimicrobial peptide Pm-amp1 showed high similarity to antimicrobial peptide marcin-18. This peptide was successfully expressed and showed moderate activity against four tested strains. These identified peptides highlight the extensive diversity of defensive peptides and provide powerful tools to understand the defense weapon of frog. |
| 收录类别 | SCIE
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/12448
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| 专题 | 科研部门_天然药物功能蛋白质学科组（赖仞）
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推荐引用方式
GB/T 7714 |
Rong, MQ,Liu, J,Liao, Q,et al. The defensive system of tree frog skin identified by peptidomics and RNA sequencing analysis[J]. AMINO ACIDS,2019,51(2):345-353.
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| APA |
Rong, MQ.,Liu, J.,Liao, Q.,Lin, ZL.,Wen, B.,...&Lai, R.(2019).The defensive system of tree frog skin identified by peptidomics and RNA sequencing analysis.AMINO ACIDS,51(2),345-353.
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| MLA |
Rong, MQ,et al."The defensive system of tree frog skin identified by peptidomics and RNA sequencing analysis".AMINO ACIDS 51.2(2019):345-353.
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