CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer

	CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer
	Feng, C; Li, YX; Lin, Y; Cao, XB; Li, DD; Zhang, HL; He, XG
	2019
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN	1107-3756
卷号	43 期号:1 页码:127-142
摘要	Accumulating evidence has suggested that circular RNAs (circRNAs), a novel class of non-coding RNAs, have crucial roles in tumor progression. However, the significance of circRNAs in hypopharyngeal cancer (HCa) remains to be investigated. The present study has identified aberrantly expressed circRNAs by performing circRNA sequencing analyses of three pairs of tumor and adjacent normal samples from patients with HCa. The results demonstrated that 173 circRNAs were differentially expressed (DE), including 71 upregulated and 102 downregulated circRNAs (FDR<0.05 and fold changes of 2 or 0.5 by Mann-Whitney U test followed by Benjamini-Hochberg correction for multiple testing). Pathway analyses of the genes producing DE circRNAs revealed that many of them were involved in cancer-related pathways. To further illustrate the roles of circRNAs in HCa progression, a competing endogenous RNA (ceRNAs) network was constructed, consisting of circRNAs, miRNA, and miRNA targeted genes. The results demonstrated that multiple cancer-related pathways were affected by performing enrichment analyses of the targeted genes. Of note, a ceRNA subnetwork was isolated, consisting of two circRNAs (hsa_circ_0008287 and hsa_circ_0005027) and one miRNA (hsa-miR-548c-3p), which significantly affect both ErbB and Hippo signaling pathways. In conclusion, the present study identified a set of circRNAs that are potentially implicated in the tumorigenesis of HCa and may serve as potential biomarkers for the diagnosis of HCa.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12453
专题	科研部门_发育的印迹调控与进化学（焦保卫）
推荐引用方式 GB/T 7714	Feng, C,Li, YX,Lin, Y,et al. CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2019,43(1):127-142.
APA	Feng, C.,Li, YX.,Lin, Y.,Cao, XB.,Li, DD.,...&He, XG.(2019).CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,43(1),127-142.
MLA	Feng, C,et al."CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 43.1(2019):127-142.

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