TNIP1 Polymorphisms with the Risk of Hepatocellular Carcinoma Based on Chronic Hepatitis B Infection in Chinese Han Population

	TNIP1 Polymorphisms with the Risk of Hepatocellular Carcinoma Based on Chronic Hepatitis B Infection in Chinese Han Population
	Cheng, YJ; Jiang, XC; Jin, JQ; Luo, XJ; Chen, WL; Li, Q; Zhang, C
	2019
发表期刊	BIOCHEMICAL GENETICS
ISSN	0006-2928
卷号	57 期号:1 页码:117-128
摘要	Chronic hepatitis B virus (HBV) infection is an important etiology for the development of hepatocellular carcinoma (HCC). Tumor necrosis factor--induced protein 3-interacting protein 1 (TNIP1) is linked to specific inflammatory diseases as a novel type of endogenous inflammatory regulator. However, presently, rare information is found about the association between TNIP1 polymorphisms and HBV-induced HCC risk. In this case control study, we genotyped four single nucleotide polymorphisms (SNPs) in TNIP1 gene in 248 HCC patients and 242 chronic HBV carriers using Sequenom Mass-ARRAY technology. Genetic model and haplotype analysis were performed to evaluate the association between candidate SNPs polymorphisms and HBV-induced HCC susceptibility using Pearson's (2) test and unconditional logistic regression analysis. Overall, we found two risk alleles in TNIP1 for HBV-induced HCC in patients: the allele G of rs7708392 by genotype model (G/C vs. C/C: OR 1.88, 95% CI 1.17-3, P=0.009) and dominant model (G/C-G/G vs. C/C: OR 1.69, 95% CI 1.08-2.65, P=0.023), and the allele C of rs10036748 by genotype model (C/T vs. T/T: OR 1.83, 95% CI 1.14-2.92, P=0.012) and dominant model (C/T-C/C vs. T/T: OR 1.65, 95% CI 1.05-2.59, P=0.03). However, rs3792792 and rs4958881 polymorphisms didn't significantly correlate with the risk of HBV-induced HCC. Haplotype analysis showed no significant association between haplotypes and the HCC risk in HBV carriers. This study provides evidence for HBV-induced HCC susceptibility gene TNIP1 in the Chinese Han population.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12454
专题	科研部门_神经系统疾病（罗雄剑）
推荐引用方式 GB/T 7714	Cheng, YJ,Jiang, XC,Jin, JQ,et al. TNIP1 Polymorphisms with the Risk of Hepatocellular Carcinoma Based on Chronic Hepatitis B Infection in Chinese Han Population[J]. BIOCHEMICAL GENETICS,2019,57(1):117-128.
APA	Cheng, YJ.,Jiang, XC.,Jin, JQ.,Luo, XJ.,Chen, WL.,...&Zhang, C.(2019).TNIP1 Polymorphisms with the Risk of Hepatocellular Carcinoma Based on Chronic Hepatitis B Infection in Chinese Han Population.BIOCHEMICAL GENETICS,57(1),117-128.
MLA	Cheng, YJ,et al."TNIP1 Polymorphisms with the Risk of Hepatocellular Carcinoma Based on Chronic Hepatitis B Infection in Chinese Han Population".BIOCHEMICAL GENETICS 57.1(2019):117-128.

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