Transcriptomic Landscape of von Economo Neurons in Human Anterior Cingulate Cortex Revealed by Microdissected-Cell RNA Sequencing

KIZ OpenIR > 科研部门 > 比较基因组学（宿兵）

	Transcriptomic Landscape of von Economo Neurons in Human Anterior Cingulate Cortex Revealed by Microdissected-Cell RNA Sequencing
	Yang, LX; Yang, YD; Yuan, JM; Sun, Y; Dai, JP; Su, B
	2019
发表期刊	CEREBRAL CORTEX
ISSN	1047-3211
卷号	29 期号:2 页码:838-851
摘要	The von Economo neurons (VENs) are specialized large bipolar projection neurons with restricted distribution in the human brain, and they are far more abundant in humans than in non-human primates. However, VEN functions remain elusive due to the difficulty of isolating VENs and dissecting their connections in the brain. Here, we combined laser-capture-microdissection with RNA sequencing to describe the transcriptomic profile of VENs from human anterior cingulate cortex (ACC). Using pyramidal neurons as reference cells, we identified 344 genes with VEN-associated expression differences, including 215 higher and 129 lower expression genes. Functional enrichment and protein-protein interaction network analyses showed that these genes with VEN-associated expression differences are involved in VEN morphogenesis and functions, such as dendrite branching and axon myelination, and many of them are associated with human social-emotional disorders. With the use of in situ hybridization and immunohistochemistry assays, we validated four novel VEN markers (VAT1L, CHST8, LYPD1, and SULF2). Collectively, we generated a full-spectrum expression profile of VENs from human ACC, greatly enlarging the pool of genes with VEN-associated expression differences that can help researchers to understand the role of VENs in normal and disordered human brains.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12548
专题	科研部门_比较基因组学（宿兵）
推荐引用方式 GB/T 7714	Yang, LX,Yang, YD,Yuan, JM,et al. Transcriptomic Landscape of von Economo Neurons in Human Anterior Cingulate Cortex Revealed by Microdissected-Cell RNA Sequencing[J]. CEREBRAL CORTEX,2019,29(2):838-851.
APA	Yang, LX,Yang, YD,Yuan, JM,Sun, Y,Dai, JP,&Su, B.(2019).Transcriptomic Landscape of von Economo Neurons in Human Anterior Cingulate Cortex Revealed by Microdissected-Cell RNA Sequencing.CEREBRAL CORTEX,29(2),838-851.
MLA	Yang, LX,et al."Transcriptomic Landscape of von Economo Neurons in Human Anterior Cingulate Cortex Revealed by Microdissected-Cell RNA Sequencing".CEREBRAL CORTEX 29.2(2019):838-851.

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2019070110.pdf（2412KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文