Modular architecture of metabolic brain network and its effects on the spread of perturbation impact

	Modular architecture of metabolic brain network and its effects on the spread of perturbation impact
	Zhang, TH; Huang, Q; Jiao, CX; Liu, H; Nie, BB; Liang, SX; Li, PL; Sun, X; Feng, T; Xu, L; Shan, BC
	2019
发表期刊	NEUROIMAGE
ISSN	1053-8119
卷号	186 页码:146-154
摘要	Metabolic brain network, which is based on functional correlation patterns of F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) images, has been widely applied in both basic and clinical neuroscience. Exploring the properties of the metabolic brain network can provide valuable insight to the physiologic and pathologic processes of the brain. Based on the network theory, modular architecture has the ability to limit the spread of local perturbation impact and therefore modular networks are more robust against external damage. However, whether the metabolic brain network has modular architecture remains unknown. Methods: 77 rats performed F-18-FDG PET brain imaging. The metabolic brain network was then constructed by measuring interregional metabolic correlation in inter-subject manner. Afterwards, modular architecture of the network was detected by a greedy algorithm. Further, we perturbed the metabolic brain network by inducing focal photothrombotic ischemia in the bilateral motor cortex and then measured the glucose metabolic change of each brain region using FDG-PET. Results: A significant modular architecture was found in the metabolic brain network. The network could be divided into four modules which corresponding approximately to executive, learning/memory, visual/auditory and sensorimotor processing functional domains. After inducing the focal ischemia on the bilateral motor cortex, most of the significantly changed brain regions (13 of 17) belong to the sensorimotor module. Conclusion: Our results revealed an inherent modular architecture in the metabolic brain network and gave an experimental evidence that the modularity of the metabolism brain network could limit the spread of local perturbation impact.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12553
专题	科研部门_学习记忆的分子神经机制（徐林）
推荐引用方式 GB/T 7714	Zhang, TH,Huang, Q,Jiao, CX,et al. Modular architecture of metabolic brain network and its effects on the spread of perturbation impact[J]. NEUROIMAGE,2019,186:146-154.
APA	Zhang, TH.,Huang, Q.,Jiao, CX.,Liu, H.,Nie, BB.,...&Shan, BC.(2019).Modular architecture of metabolic brain network and its effects on the spread of perturbation impact.NEUROIMAGE,186,146-154.
MLA	Zhang, TH,et al."Modular architecture of metabolic brain network and its effects on the spread of perturbation impact".NEUROIMAGE 186(2019):146-154.

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