| Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma |
| Yang, H; Mo, CZ; Xun, Y; Liu, LG; Li, WX; Guan, JY; Liu, J; Wu, JQ; Yang, AP; Zheng, SG; Liu, DH; Liu, F
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| 2019
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| 发表期刊 | AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
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| ISSN | 1943-8141
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| 卷号 | 11期号:4页码:2370-2381 |
| 摘要 | Objective: To investigate the underlying molecular mechanisms contributing to oral squamous cell carcinoma (OSCC) cell resistance to the epidermal growth factor receptor (EGFR) inhibitor. Materials and methods: OSCC cell lines HSC-2 and HSC-3 were assessed in vitro for drug treatment, cell viability, and gene expression and the online gene expression in OSCC tissues was analyzed for association with OSCC prognosis. Results: HSC-2 and HSC-3 cells expressed high EGFR levels, but hepatocyte growth factor (HGF) treatment induced cetuximab resistance, whereas the Met inhibitor PHA-665752 as well as Met siRNA was able to restore OSCC cell sensitivity to cetuximab. HGF treatment induced tumor cells to express p-Akt and p-ERK1/2. In contrast, the activity of Akt and ERK1/2 was suppressed by treatment with PHA-665752, Met siRNA, or their combination. Furthermore, Met was highly expressed in OSCC tissues and associated with a poor patient survival, while Met/HGF-activated Akt also was associated with a poor patient survival. Conclusions: This study demonstrates that Met/HGF expression results in OSCC resistance to cetuximab and tumor recurrence after cetuximab therapy; thus, inhibition of Met/HGF activity could restore OSCC sensitivity to cetuximab. |
| 收录类别 | SCIE
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/12555
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| 专题 | 科研部门_学习记忆的分子神经机制（徐林）
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推荐引用方式
GB/T 7714 |
Yang, H,Mo, CZ,Xun, Y,et al. Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2019,11(4):2370-2381.
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| APA |
Yang, H.,Mo, CZ.,Xun, Y.,Liu, LG.,Li, WX.,...&Liu, F.(2019).Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,11(4),2370-2381.
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| MLA |
Yang, H,et al."Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 11.4(2019):2370-2381.
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