| Transcriptome analysis of spleen reveals the signal transduction of toll-like receptors after Aeromonas hydrophila infection in Schizothorax prenanti |
| Li, YK; Wu, JY; Li, D; Huang, AQ; Bu, GX; Meng, FY; Kong, FL; Cao, XH; Han, XF; Pan, XF; Fan, W; Yang, SY; Zeng, XY; Du, XG
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| 2019
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| 发表期刊 | FISH & SHELLFISH IMMUNOLOGY
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| ISSN | 1050-4648
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| 卷号 | 84页码:816-824 |
| 摘要 | Schizothorax prenatal (S. prencmd), an important species of economical fish in Southwest China, is susceptible to Aeromonas hydrophila (Ah). To understand the immune response to Ah, the transcriptome profiling of spleen of S. prenanti was analyzed after Ah infection. A total of 6, 213 different expression genes (DEGs) were obtained, including 3, 066 up-regulated DEGs and 3, 147 down-regulated DEGs. These DEGs were annotated by KEGG and GO databases, so that the immune-related DEGs (IRDs) can be identified and classified. Then, the interesting IRDs were screened to build heat map, and the reliability of the transcriptome data was validated by qPCR. In order to clarify the mechanism of signal transduction in the anti-bacterial immunity, the signaling pathway initiated by TLRs was predicted. In this pathway, TLR25 and TLR5 mediate the NF-kappa B and AP-1 signals via MyD88-dependent pathway. Meanwhile, the type I IFN (IFN alpha/beta) induced by IRF1 and IRF3/7 may play an important role in the anti-bacterial immunity. In conclusion, this study preliminarily provides insights into the mechanism of signal transduction after Ah infection in S. prenanti, which contributes to exploring the complex anti-bacterial immunity. |
| 收录类别 | SCIE
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/12562
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| 专题 | 科研部门_系统进化与生物地理学（杨君兴）
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推荐引用方式
GB/T 7714 |
Li, YK,Wu, JY,Li, D,et al. Transcriptome analysis of spleen reveals the signal transduction of toll-like receptors after Aeromonas hydrophila infection in Schizothorax prenanti[J]. FISH & SHELLFISH IMMUNOLOGY,2019,84:816-824.
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| APA |
Li, YK.,Wu, JY.,Li, D.,Huang, AQ.,Bu, GX.,...&Du, XG.(2019).Transcriptome analysis of spleen reveals the signal transduction of toll-like receptors after Aeromonas hydrophila infection in Schizothorax prenanti.FISH & SHELLFISH IMMUNOLOGY,84,816-824.
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| MLA |
Li, YK,et al."Transcriptome analysis of spleen reveals the signal transduction of toll-like receptors after Aeromonas hydrophila infection in Schizothorax prenanti".FISH & SHELLFISH IMMUNOLOGY 84(2019):816-824.
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