Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia

	Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia
	Li, Jingzheng; Shang, Yafang; Wang, Lin; Zhao, Bo; Sun, Chunli; Li, Jiali; Liu, Siling; Li, Cong; Tang, Min; Meng, Fei-Long; Zheng, Ping
	2020
发表期刊	SCIENCE ADVANCES
ISSN	2375-2548
卷号	6 期号:44
摘要	Endogenous DNA double-strand breaks (DSBs) formation and repair in neural stem/progenitor cells (NSPCs) play fundamental roles in neurogenesis and neurodevelopmental disorders. NSPCs exhibit heterogeneity in terms of lineage fates and neurogenesis activity. Whether NSPCs also have heterogeneous regulations on DSB formation and repair to accommodate region-specific neurogenesis has not been explored. Here, we identified a regional regulator Filia, which is predominantly expressed in mouse hippocampal NSPCs after birth and regulates DNA DSB formation and repair. On one hand, Filia protects stalling replication forks and prevents the replication stress-associated DNA DSB formation. On the other hand, Filia facilitates the homologous recombination-mediated DNA DSB repair. Consequently, Filia(-/-) mice had impaired hippocampal NSPC proliferation and neurogenesis and were deficient in learning, memory, and mood regulations. Thus, our study provided the first proof of concept demonstrating the region-specific regulations of DSB formation and repair in subtypes of NSPCs.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12673
专题	科研部门_哺乳动物胚胎发育（郑萍）
推荐引用方式 GB/T 7714	Li, Jingzheng,Shang, Yafang,Wang, Lin,et al. Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia[J]. SCIENCE ADVANCES,2020,6(44).
APA	Li, Jingzheng.,Shang, Yafang.,Wang, Lin.,Zhao, Bo.,Sun, Chunli.,...&Zheng, Ping.(2020).Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia.SCIENCE ADVANCES,6(44).
MLA	Li, Jingzheng,et al."Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia".SCIENCE ADVANCES 6.44(2020).

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