Hypoxia and cancer related pathology

	Hypoxia and cancer related pathology
	Xiong, Qiuxia; Liu, Baiyang; Ding, Mingxia; Zhou, Jumin; Yang, Cuiping; Chen, Yongbin
	2020
发表期刊	CANCER LETTERS
ISSN	0304-3835
卷号	486 页码:1-7
摘要	Hypoxic environments occur normally at high altitude, or in underground burrows and in deep sea habitats. They also occur pathologically in human ischemia and in hypoxic solid tumors. Hypoxia in various cancer types and its related molecular mechanisms are associated with a poor clinical outcome. This review will discuss how hypoxia can influence two aspects of tumorigenesis, namely the direct, cell-intrinsic oncogenic effects, as well as the indirect effects on tumor progression mediated by an altered tumor microenvironment. We will also discuss recent progress in identifying the functional roles of hypoxia-related factors (HIFs), along with their regulators and downstream target genes, in cancer stem cells and therapy. Importantly, we propose, using convergent evolution schemes to identify novel biomarkers for both hypoxia adaptation and hypoxic solid tumors as an important strategy in the future.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12677
专题	科研部门_基因调控与表达遗传（周巨民）
推荐引用方式 GB/T 7714	Xiong, Qiuxia,Liu, Baiyang,Ding, Mingxia,et al. Hypoxia and cancer related pathology[J]. CANCER LETTERS,2020,486:1-7.
APA	Xiong, Qiuxia,Liu, Baiyang,Ding, Mingxia,Zhou, Jumin,Yang, Cuiping,&Chen, Yongbin.(2020).Hypoxia and cancer related pathology.CANCER LETTERS,486,1-7.
MLA	Xiong, Qiuxia,et al."Hypoxia and cancer related pathology".CANCER LETTERS 486(2020):1-7.

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2021102502.pdf（803KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文