HIV-1 Drug Resistance in ART-Naive Individuals in Myanmar

	HIV-1 Drug Resistance in ART-Naive Individuals in Myanmar
	Ye, Mei; Chen, Xin; Wang, Yu; Zhou, Yan-Heng; Pang, Wei; Zhang, Chiyu; Zheng, Yong-Tang
	2020
发表期刊	INFECTION AND DRUG RESISTANCE
ISSN	1178-6973
卷号	13 页码:1123-1132
摘要	Background: Estimating the prevalence and characterizing the transmission of HIV-1 drug resistance in treatment-naive individuals are very important in the prevention and control of HIV/AIDS. As one of the areas most affected by HIV/AIDS, few data are currently available for HIV-1 drug resistance in antiretroviral therapy (ART)-naive individuals in Myanmar, which borders Yunnan, China.Methods: HIV-1 pol sequences from ART-naive HIV-1-infected individuals during 2008 and 2014 in Myanmar were retrieved from our previous studies. HIV-1 transmitted drug resistance (TDR) and susceptibility to antiretroviral drugs were predicted using the Stanford HIVdb program. HIV-1 transmission cluster (TC) was determined by Cluster Picker.Results: A total of 169 partial pol sequences from ART-naive HIV-1 positive Burmese were analyzed. The prevalence of TDR was 20.1%. CRF01_AE and BC recombinants appeared to have a higher prevalence of TDR than other subtypes. The V179D/T was found to be very common in the China-Myanmar border region and was involved in half of the transmission clusters formed by HIV-1 drug-resistance strains in this region. Comparison showed that drug-resistance mutation profile in Myanmar was very similar to that in Dehong prefecture of Yunnan. By further phylogenetic analysis with all available sequences from the China-Myanmar border region, four HIV-1 drug-resistance-related TCs were identified. Three of them were formed by Burmese long-distance truck drivers and the Burmese staying in Yunnan, and another was formed by Burmese injection drug users staying in Myanmar and Yunnan. These results suggest a potential transmission link of HIV-1 drug resistance between Myanmar and Yunnan.Conclusion: Given the high prevalence of TDR in Myanmar, and the potential risk of cross-border transmission of HIV-1 drug-resistant strains between Myanmar and Yunnan, China, ongoing monitoring of HIV-1 drug resistance in ART-naive individuals will provide a guideline for clinical antiretroviral treatment and benefit the prevention and control of HIV/AIDS in this border region.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12683
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Ye, Mei,Chen, Xin,Wang, Yu,et al. HIV-1 Drug Resistance in ART-Naive Individuals in Myanmar[J]. INFECTION AND DRUG RESISTANCE,2020,13:1123-1132.
APA	Ye, Mei.,Chen, Xin.,Wang, Yu.,Zhou, Yan-Heng.,Pang, Wei.,...&Zheng, Yong-Tang.(2020).HIV-1 Drug Resistance in ART-Naive Individuals in Myanmar.INFECTION AND DRUG RESISTANCE,13,1123-1132.
MLA	Ye, Mei,et al."HIV-1 Drug Resistance in ART-Naive Individuals in Myanmar".INFECTION AND DRUG RESISTANCE 13(2020):1123-1132.

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