Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques

	Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques
	Song, Tian-Zhang; Zheng, Hong-Yi; Han, Jian-Bao; Jin, Lin; Yang, Xiang; Liu, Feng-Liang; Luo, Rong-Hua; Tian, Ren-Rong; Cai, Hou-Rong; Feng, Xiao-Li; Liu, Chao; Li, Ming-Hua; Zheng, Yong-Tang
	2020
发表期刊	ZOOLOGICAL RESEARCH
ISSN	2095-8137
卷号	41 期号:5 页码:503-516
摘要	As of June 2020, Coronavirus Disease 2019 (COVID-19) has killed an estimated 440 000 people worldwide, 74% of whom were aged >= 65 years, making age the most significant risk factor for death caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To examine the effect of age on death, we established a SARSCoV-2 infection model in Chinese rhesus macaques (Macaca mulatta) of varied ages. Results indicated that infected young macaques manifested impaired respiratory function, active viral replication, severe lung damage, and infiltration of CD11b(+) and CD8(+) cells in lungs at one-week post infection (wpi), but also recovered rapidly at 2 wpi. In contrast, aged macaques demonstrated delayed immune responses with a more severe cytokine storm, increased infiltration of CD11b(+) cells, and persistent infiltration of CD8(+) cells in the lungs at 2 wpi. In addition, peripheral blood T cells from aged macaques showed greater inflammation and chemotaxis, but weaker antiviral functions than that in cells from young macaques. Thus, the delayed but more severe cytokine storm and higher immune cell infiltration may explain the poorer prognosis of older aged patients suffering SARS-CoV-2 infection.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12684
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Song, Tian-Zhang,Zheng, Hong-Yi,Han, Jian-Bao,et al. Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques[J]. ZOOLOGICAL RESEARCH,2020,41(5):503-516.
APA	Song, Tian-Zhang.,Zheng, Hong-Yi.,Han, Jian-Bao.,Jin, Lin.,Yang, Xiang.,...&Zheng, Yong-Tang.(2020).Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques.ZOOLOGICAL RESEARCH,41(5),503-516.
MLA	Song, Tian-Zhang,et al."Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques".ZOOLOGICAL RESEARCH 41.5(2020):503-516.

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