TRPC1 participates in the HSV-1 infection process by facilitating viral entry

	TRPC1 participates in the HSV-1 infection process by facilitating viral entry
	He, DongXu; Mao, AiQin; Li, YouRan; Tam, SiuCheung; Zheng, YongTang; Yao, XiaoQiang; Birnbaumer, Lutz; Ambudkar, Indu S.; Ma, Xin
	2020
发表期刊	SCIENCE ADVANCES
ISSN	2375-2548
卷号	6 期号:12
摘要	Mammalian transient receptor potential (TRP) channels are major components of Ca2+ signaling pathways and control a diversity of physiological functions. Here, we report a specific role for TRPC1 in the entry of herpes simplex virus type 1 (HSV-1) into cells. HSV-1-induced Ca2+ release and entry were dependent on Orai1, STIM1, and TRPC1. Inhibition of Ca2+ entry or knockdown of these proteins attenuated viral entry and infection. HSV-1 glycoprotein D interacted with the third ectodomain of TRPC1, and this interaction facilitated viral entry. Knockout of TRPC1 attenuated HSV-1-induced ocular abnormality and morbidity in vivo in TRPC1(-/-) mice. There was a strong correlation between HSV-1 infection and plasma membrane localization of TRPC1 in epithelial cells within oral lesions in buccal biopsies from HSV-1-infected patients. Together, our findings demonstrate a critical role for TRPC1 in HSV-1 infection and suggest the channel as a potential target for anti-HSV therapy.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12686
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	He, DongXu,Mao, AiQin,Li, YouRan,et al. TRPC1 participates in the HSV-1 infection process by facilitating viral entry[J]. SCIENCE ADVANCES,2020,6(12).
APA	He, DongXu.,Mao, AiQin.,Li, YouRan.,Tam, SiuCheung.,Zheng, YongTang.,...&Ma, Xin.(2020).TRPC1 participates in the HSV-1 infection process by facilitating viral entry.SCIENCE ADVANCES,6(12).
MLA	He, DongXu,et al."TRPC1 participates in the HSV-1 infection process by facilitating viral entry".SCIENCE ADVANCES 6.12(2020).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2021102507.pdf（5219KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文