Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques

	Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques
	Shan, Chao; Yao, Yan-Feng; Yang, Xing-Lou; Zhou, Yi-Wu; Gao, Ge; Peng, Yun; Yang, Lian; Hu, Xue; Xiong, Jin; Jiang, Ren-Di; Zhang, Hua-Jun; Gao, Xiao-Xiao; Peng, Cheng; Min, Juan; Chen, Ying; Si, Hao-Rui; Wu, Jia; Zhou, Peng; Wang, Yan-Yi; Wei, Hong-Ping; Pang, Wei; Hu, Zheng-Fei; Lv, Long-Bao; Zheng, Yong-Tang; Shi, Zheng-Li; Yuan, Zhi-Ming
	2020
发表期刊	CELL RESEARCH
ISSN	1001-0602
卷号	30 期号:8 页码:670-677
摘要	The 2019 novel coronavirus (SARS-CoV-2) outbreak is a major challenge for public health. SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases, with a mortality rate of similar to 6.4% worldwide (based on World Health Organization daily situation report). However, the dynamics of viral infection, replication and shedding are poorly understood. Here, we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2. After intratracheal inoculation, the first peak of viral RNA was observed in oropharyngeal swabs one day post infection (1 d.p.i.), mainly from the input of the inoculation, while the second peak occurred at 5 d.p.i., which reflected on-site replication in the respiratory tract. Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals, characterized by hyperemia and edema, and infiltration of monocytes and lymphocytes in alveoli. We also identified SARS-CoV-2 RNA in respiratory tract tissues, including trachea, bronchus and lung; and viruses were also re-isolated from oropharyngeal swabs, bronchus and lung, respectively. Furthermore, we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a secondround challenge by SARS-CoV-2. The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12690
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Shan, Chao,Yao, Yan-Feng,Yang, Xing-Lou,et al. Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques[J]. CELL RESEARCH,2020,30(8):670-677.
APA	Shan, Chao.,Yao, Yan-Feng.,Yang, Xing-Lou.,Zhou, Yi-Wu.,Gao, Ge.,...&Yuan, Zhi-Ming.(2020).Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques.CELL RESEARCH,30(8),670-677.
MLA	Shan, Chao,et al."Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques".CELL RESEARCH 30.8(2020):670-677.

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