Daphnane Diterpenoids from Trigonostemon lii and Inhibition Activities Against HIV-1.

	Daphnane Diterpenoids from Trigonostemon lii and Inhibition Activities Against HIV-1.
	Tan, Cheng-Jian; Li, Shi-Fei; Huang, Ning; Zhang, Yu; Di, Ying-Tong; Zheng, Yong-Tang; Hao, Xiao-Jiang
	2020
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	10 期号:1 页码:37-44
摘要	Natural products are the important source for the discovery of more potent anti-HIV agents. In this study, six daphnane diterpenoids including three unreported structures were isolated from Trigonostemon lii, which showed significant activities against HIV-1 strains replication in the nanomolar/picomolar range. Meanwhile, these diterpenoids significantly inhibited the fusion of H9/HIV-1 IIIB cells with uninfected C8166 cells, with the EC50s from 1.06 to 8.73ng/mL, and did not show any inhibition activities against HIV-1 reverse transcriptase. Moreover, all of the diterpenoids shows significant inhibitions against T20-resistan HIV-1 strains, PNL4-3gp41(36G)V38E, N42S and pNL4-3gp41(36G)V38A, N42T. The results revealed that the six diterpenoids could be a new type of potential lead candidate as an HIV entry inhibitor, particularly for those infected by T20-resistant variants.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12693
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Tan, Cheng-Jian,Li, Shi-Fei,Huang, Ning,et al. Daphnane Diterpenoids from Trigonostemon lii and Inhibition Activities Against HIV-1.[J]. Natural products and bioprospecting,2020,10(1):37-44.
APA	Tan, Cheng-Jian.,Li, Shi-Fei.,Huang, Ning.,Zhang, Yu.,Di, Ying-Tong.,...&Hao, Xiao-Jiang.(2020).Daphnane Diterpenoids from Trigonostemon lii and Inhibition Activities Against HIV-1..Natural products and bioprospecting,10(1),37-44.
MLA	Tan, Cheng-Jian,et al."Daphnane Diterpenoids from Trigonostemon lii and Inhibition Activities Against HIV-1.".Natural products and bioprospecting 10.1(2020):37-44.

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