| Osteoking improves OP rat by enhancing HSP90-beta expression | |
| Sun, Yan; Chen, Ran; Zhu, Di; Shen, Zhi-Qiang; Zhao, Hong-Bin; Lee, Wen-Hui | |
| 2020 | |
| 发表期刊 | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
 |
| ISSN | 1107-3756 |
| 卷号 | 45期号:5页码:1543-1553 |
| 摘要 | Osteoporosis (OP) is a chronic bone disease that affects individuals worldwide. Osteoporosis is primarily asymptomatic, and patients with OP suffer from pain, inconvenience, economic pressure and osteoporotic fracture (OPF). Osteoking, a Traditional Chinese Medicine compound that originates from the Yi ethnic group, has been used for a number of years to treat fractures. In our previous study, osteoking exhibited therapeutic effects on rats with OPF by promoting calcium deposition. Based on bioinformatics and network pharmacology analyses of a component-target-disease database, heat shock protein HSP 90-beta (HSP90-beta), also known as HSP90-beta, was identified to be a key target of osteoking in OP. High HSP90-beta expression levels were observed in osteoporotic rats and rat bone mesenchymal stem cells (rBMSCs) following osteoking treatment. After 12 weeks of administration in vivo, there was increased bone mineral density (BMD) (P<0.05), increased bone alkaline phosphatase (P<0.05), and improved bone microstructure in the osteoking group compared with those of the negative control group. In vitro, increased calcium deposition in rBMSCs was observed after 4 weeks of osteoking treatment. These results suggest that the mechanisms of osteoking are closely associated with HSP90-beta and activate the bone morphogenetic protein (BMP) signalling pathway, primarily through BMP-2. Osteoking treatment improves OP in rats by enhancing HSP90-beta expression. |
| 收录类别 | sci |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/12701 |
| 专题 | 科研部门_生物毒素与人类疾病（张云） |
| 推荐引用方式 GB/T 7714 | Sun, Yan,Chen, Ran,Zhu, Di,et al. Osteoking improves OP rat by enhancing HSP90-beta expression[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2020,45(5):1543-1553. |
| APA | Sun, Yan,Chen, Ran,Zhu, Di,Shen, Zhi-Qiang,Zhao, Hong-Bin,&Lee, Wen-Hui.(2020).Osteoking improves OP rat by enhancing HSP90-beta expression.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,45(5),1543-1553. |
| MLA | Sun, Yan,et al."Osteoking improves OP rat by enhancing HSP90-beta expression".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 45.5(2020):1543-1553. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2021110106.pdf（1120KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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