Tupaia MAVS Is a Dual Target during Hepatitis C Virus Infection for Innate Immune Evasion and Viral Replication via NF-kappa B

KIZ OpenIR > 科研部门 > 疾病机理遗传学和进化医学学科组（姚永刚）

	Tupaia MAVS Is a Dual Target during Hepatitis C Virus Infection for Innate Immune Evasion and Viral Replication via NF-kappa B
	Xu, Ling; Yu, Dandan; Yao, Yu-Lin; Gu, Tianle; Zheng, Xiao; Wu, Yong; Luo, Rong-Hua; Zheng, Yong-Tang; Zhong, Jin; Yao, Yong-Gang
	2020
发表期刊	JOURNAL OF IMMUNOLOGY
ISSN	0022-1767
卷号	205 期号:8 页码:2091-2099
摘要	Hepatitis C virus (HCV) infection is the cause of severe liver disease in many people. The restricted species tropism of HCV hinders the research and development of drugs and vaccines. The Chinese tree shrew (Tupaia belangeri chinensis) is a close relative of primates and can be infected by HCV, but the underlying mechanisms are unknown. In this study, we have characterized the functions of tree shrew MAVS (tMAVS) in response to HCV infection and defined the capacity of HCV replication. HCV was shown to be colocalized with tMAVS in primary tree shrew hepatocytes and cleaved tMAVS at site Cys508 via its NS3/4A protease, with a modulating effect by site Glu(506) of tMAVS. The tMAVS cleavage by HCV NS3/4A impaired the IRF3-mediated induction of IFN-beta but maintained the activated NF-kappa B signaling in the tree shrew primary cells. Activation of the tMAVS-dependent NF-kappa B signaling inversely inhibited HCV replication and might limit the establishment of persistent infection. Overall, our study has revealed an elegant example of the balance between the host defenses and HCV infection via the MAVS-mediated antiviral signaling and has provided an insight into the mechanisms underpinning HCV infection in the Chinese tree shrew.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12743
专题	科研部门_疾病机理遗传学和进化医学学科组（姚永刚）
推荐引用方式 GB/T 7714	Xu, Ling,Yu, Dandan,Yao, Yu-Lin,et al. Tupaia MAVS Is a Dual Target during Hepatitis C Virus Infection for Innate Immune Evasion and Viral Replication via NF-kappa B[J]. JOURNAL OF IMMUNOLOGY,2020,205(8):2091-2099.
APA	Xu, Ling.,Yu, Dandan.,Yao, Yu-Lin.,Gu, Tianle.,Zheng, Xiao.,...&Yao, Yong-Gang.(2020).Tupaia MAVS Is a Dual Target during Hepatitis C Virus Infection for Innate Immune Evasion and Viral Replication via NF-kappa B.JOURNAL OF IMMUNOLOGY,205(8),2091-2099.
MLA	Xu, Ling,et al."Tupaia MAVS Is a Dual Target during Hepatitis C Virus Infection for Innate Immune Evasion and Viral Replication via NF-kappa B".JOURNAL OF IMMUNOLOGY 205.8(2020):2091-2099.

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