SZDB2.0: an updated comprehensive resource for schizophrenia research

KIZ OpenIR > 科研部门 > 疾病机理遗传学和进化医学学科组（姚永刚）

	SZDB2.0: an updated comprehensive resource for schizophrenia research
	Wu, Yong; Li, Xiaoyan; Liu, Jiewei; Luo, Xiong-Jian; Yao, Yong-Gang
	2020
发表期刊	HUMAN GENETICS
ISSN	0340-6717
卷号	139 期号:10 页码:1285-1297
摘要	During the past decade, genetic studies of schizophrenia have become one of the most exciting and fast-moving areas. Hundreds of genes implicated in schizophrenia have been identified by genetic, epigenetic, and gene expression studies. However, how to systematically and efficiently use these published data to pinpoint the causal genes becomes a major challenge in schizophrenia research. Here, we release an updated version of a comprehensive database for schizophrenia research, SZDB2.0 (), which accompanies significant data expansion and feature improvements, as well as functionality optimization. Compared with the first version (SZDB), the current database has the following updates: (1) We added the newly published genome-wide association study (GWAS) of schizophrenia from CLOZUK + PGC, which is the largest GWAS for schizophrenia; (2) We included a polygenic risk score calculator; (3) In the refined Gene module of SZDB2.0, we collated genetic, gene expression, methylation, and integrative results of all available schizophrenia studies; (4) In the CNV (copy number variation) module, we collated the results of all 77 CNV publications about schizophrenia; (5) We also updated other data, including gene expression quantitative trait loci (eQTL), transcript QTL, methylation QTL, and protein-protein interaction data, based on the information from the latest literatures. We optimized the query interface of SZDB2.0 for a better visualization and data retrieval. The updated SZDB2.0 will advance the research of schizophrenia.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12748
专题	科研部门_疾病机理遗传学和进化医学学科组（姚永刚）
推荐引用方式 GB/T 7714	Wu, Yong,Li, Xiaoyan,Liu, Jiewei,et al. SZDB2.0: an updated comprehensive resource for schizophrenia research[J]. HUMAN GENETICS,2020,139(10):1285-1297.
APA	Wu, Yong,Li, Xiaoyan,Liu, Jiewei,Luo, Xiong-Jian,&Yao, Yong-Gang.(2020).SZDB2.0: an updated comprehensive resource for schizophrenia research.HUMAN GENETICS,139(10),1285-1297.
MLA	Wu, Yong,et al."SZDB2.0: an updated comprehensive resource for schizophrenia research".HUMAN GENETICS 139.10(2020):1285-1297.

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