Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation

KIZ OpenIR > 科研部门 > 疾病机理遗传学和进化医学学科组（姚永刚）

	Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation
	Liu, Qianjin; Su, Ling-Yan; Sun, Chunli; Jiao, Lijin; Miao, Ying; Xu, Min; Luo, Rongcan; Zuo, Xin; Zhou, Rongbin; Zheng, Ping; Xiong, Wei; Xue, Tian; Yao, Yong-Gang
	2020
发表期刊	REDOX BIOLOGY
ISSN	2213-2317
卷号	34
摘要	Morphine is frequently used for pain relief, but long-term morphine therapy in patients with chronic pain results in analgesic tolerance and hyperalgesia. There are no effective therapeutic treatments that limit these detri- mental side effects. We found pretreatment with melatonin could decrease morphine-induced analgesic toler- ance. There was a significant activation of the NLRP3 inflammasome in the prefrontal cortex and the peripheral blood of morphine-treated mice compared to control animals, which could be blocked by melatonin. The in- flammasome activation induced by morphine was mediated by the microglia. SiRNA knockdown or pharma- cological inhibition of the NLRP3 abolished the morphine-induced inflammasome activation. Co-administration of melatonin and low-dose morphine had better analgesia effects in the murine models of pain and led to a lower NLRP3 inflammasome activity in brain tissues. Mice deficient for Nlrp3 had a higher nociceptive threshold and were less sensitive to develop morphine-induced analgesic tolerance and acetic acid-induced pain relative to wild-type animals. Concordantly, we observed a significantly elevated level of serum IL-1 beta, which indicates an increase of NLRP3 inflammasome activity associated with the reduced level of serum melatonin, in heroin- addicted patients relative to healthy individuals. Our results provide a solid basis for conducting a clinical trial with the co-administration of melatonin and morphine for the relief of severe pain.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12750
专题	科研部门_疾病机理遗传学和进化医学学科组（姚永刚）
推荐引用方式 GB/T 7714	Liu, Qianjin,Su, Ling-Yan,Sun, Chunli,et al. Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation[J]. REDOX BIOLOGY,2020,34.
APA	Liu, Qianjin.,Su, Ling-Yan.,Sun, Chunli.,Jiao, Lijin.,Miao, Ying.,...&Yao, Yong-Gang.(2020).Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation.REDOX BIOLOGY,34.
MLA	Liu, Qianjin,et al."Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation".REDOX BIOLOGY 34(2020).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2021110309.pdf（3505KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文