COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2

KIZ OpenIR > 科研部门 > 疾病机理遗传学和进化医学学科组（姚永刚）

	COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2
	Xu, Ling; Yu, Dan-Dan; Ma, Yu-Hua; Yao, Yu-Lin; Luo, Rong-Hua; Feng, Xiao-Li; Cai, Hou-Rong; Han, Jian-Bao; Wang, Xue-Hui; Li, Ming-Hua; Ke, Chang-Wen; Zheng, Yong-Tang; Yao, Yong-Gang
	2020
发表期刊	ZOOLOGICAL RESEARCH
ISSN	2095-8137
卷号	41 期号:5 页码:517-526
摘要	The coronavirus disease 2019 (COVID-19) pandemic continues to pose a global threat to the human population. Identifying animal species susceptible to infection with the SARS-CoV-2/HCoV-19 pathogen is essential for controlling the outbreak and for testing valid prophylactics or therapeutics based on animal model studies. Here, different aged Chinese tree shrews (adult group, 1 year old; old group, 5-6 years old), which are close relatives to primates, were infected with SARS-CoV-2. X-ray, viral shedding, laboratory, and histological analyses were performed on different days post-inoculation (dpi). Results showed that Chinese tree shrews could be infected by SARS-CoV-2. Lung infiltrates were visible in X-ray radiographs in most infected animals. Viral RNA was consistently detected in lung tissues from infected animals at 3, 5, and 7 dpi, along with alterations in related parameters from routine blood tests and serum biochemistry, including increased levels of aspartate aminotransferase (AST) and blood urea nitrogen (BUN). Histological analysis of lung tissues from animals at 3 dpi (adult group) and 7 dpi (old group) showed thickened alveolar septa and interstitial hemorrhage. Several differences were found between the two different aged groups in regard to viral shedding peak. Our results indicate that Chinese tree shrews have the potential to be used as animal models for SARS-CoV-2 infection.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12755
专题	科研部门_疾病机理遗传学和进化医学学科组（姚永刚）
推荐引用方式 GB/T 7714	Xu, Ling,Yu, Dan-Dan,Ma, Yu-Hua,et al. COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2[J]. ZOOLOGICAL RESEARCH,2020,41(5):517-526.
APA	Xu, Ling.,Yu, Dan-Dan.,Ma, Yu-Hua.,Yao, Yu-Lin.,Luo, Rong-Hua.,...&Yao, Yong-Gang.(2020).COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2.ZOOLOGICAL RESEARCH,41(5),517-526.
MLA	Xu, Ling,et al."COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2".ZOOLOGICAL RESEARCH 41.5(2020):517-526.

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2021110314.pdf（10363KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文