A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice

KIZ OpenIR > 科研部门 > 疾病机理遗传学和进化医学学科组（姚永刚）

	A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice
	An, Kai; Zhao, Huan; Miao, Ying; Xu, Qi; Li, Yu-Fei; Ma, Yu-Qian; Shi, Yi-Ming; Shen, Jia-Wei; Meng, Jian-Jun; Yao, Yong-Gang; Zhang, Zhi; Chen, Ju-Tao; Bao, Jin; Zhang, Mei; Xue, Tian
	2020
发表期刊	NATURE NEUROSCIENCE
ISSN	1097-6256
卷号	23 期号:7 页码:869
摘要	Besides generating vision, light modulates various physiological functions, including mood. While light therapy applied in the daytime is known to have anti-depressive properties, excessive light exposure at night has been reportedly associated with depressive symptoms. The neural mechanisms underlying this day-night difference in the effects of light are unknown. Using a light-at-night (LAN) paradigm in mice, we showed that LAN induced depressive-like behaviors without disturbing the circadian rhythm. This effect was mediated by a neural pathway from retinal melanopsin-expressing ganglion cells to the dorsal perihabenular nucleus (dpHb) to the nucleus accumbens (NAc). Importantly, the dpHb was gated by the circadian rhythm, being more excitable at night than during the day. This indicates that the ipRGC -> dpHb -> NAc pathway preferentially conducts light signals at night, thereby mediating LAN-induced depressive-like behaviors. These findings may be relevant when considering the mental health effects of the prevalent nighttime illumination in the industrial world.An et al. discovered a new brain pathway in mice that conveys light signals from the retina to mood-relevant subcortical nuclei under circadian gating and thereby mediates depressive-like behaviors induced by abnormal nighttime light exposure.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12756
专题	科研部门_疾病机理遗传学和进化医学学科组（姚永刚）
推荐引用方式 GB/T 7714	An, Kai,Zhao, Huan,Miao, Ying,et al. A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice[J]. NATURE NEUROSCIENCE,2020,23(7):869.
APA	An, Kai.,Zhao, Huan.,Miao, Ying.,Xu, Qi.,Li, Yu-Fei.,...&Xue, Tian.(2020).A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice.NATURE NEUROSCIENCE,23(7),869.
MLA	An, Kai,et al."A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice".NATURE NEUROSCIENCE 23.7(2020):869.

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