Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors

	Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors
	Ye, Yan-Song; Du, Shu-Zong; Jiang, Na-Na; Xu, Hong-Xi; Yang, Jian; Fu, Wen-Wei; Nian, Yin; Xu, Gang
	2020
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	22 期号:16 页码:6339-6343
摘要	Hypulatones A and B (1 and 2), two racemic meroterpenoids possessing an unprecedented spiro[benzofuran-2,1'-cycloundecan]-4'-ene-4,6(5H)-dione core, were characterized from Hypericum patulum. Compound 2 was found to significantly inhibit the late current of Na(v)1.5 (late I-Na, IC50 = 0.2 mu M). Importantly, 2 exhibited remarkable separation (>100-fold) of late I-Na relative to peak I-Na and notable selectivity over Ca(v)3.1, K(v)1.5, and hERG. 1 showed comparable inhibition on late I-Na compared to that of 2 with poorer selectivity.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12775
专题	科研部门_离子通道药物研发中心（杨建）
推荐引用方式 GB/T 7714	Ye, Yan-Song,Du, Shu-Zong,Jiang, Na-Na,et al. Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors[J]. ORGANIC LETTERS,2020,22(16):6339-6343.
APA	Ye, Yan-Song.,Du, Shu-Zong.,Jiang, Na-Na.,Xu, Hong-Xi.,Yang, Jian.,...&Xu, Gang.(2020).Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors.ORGANIC LETTERS,22(16),6339-6343.
MLA	Ye, Yan-Song,et al."Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors".ORGANIC LETTERS 22.16(2020):6339-6343.

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