CDK4/6 regulate lysosome biogenesis through TFEB/TFE3

	CDK4/6 regulate lysosome biogenesis through TFEB/TFE3
	Yin, Qiuyuan; Jian, Youli; Xu, Meng; Huang, Xiahe; Wang, Niya; Liu, Zhifang; Li, Qian; Li, Jinglin; Zhou, Hejiang; Xu, Lin; Wang, Yingchun; Yang, Chonglin
	2020
发表期刊	JOURNAL OF CELL BIOLOGY
ISSN	0021-9525
卷号	219 期号:8
摘要	Lysosomes are degradation and signaling organelles that adapt their biogenesis to meet many different cellular demands; however, it is unknown how lysosomes change their numbers for cell division. Here, we report that the cyclin-dependent kinases CDK4/6 regulate lysosome biogenesis during the cell cycle. Chemical or genetic inactivation of CDK4/6 increases lysosomal numbers by activating the lysosome and autophagy transcription factors TFEB and TFE3. CDK4/6 interact with and phosphorylate TFEB/TFE3 in the nucleus, thereby inactivating them by promoting their shuttling to the cytoplasm. During the cell cycle, lysosome numbers increase in S and G2/M phases when cyclin D turnover diminishes CDK4/6 activity. These findings not only uncover the molecular events that direct the nuclear export of TFEB/TFE3, but also suggest a mechanism that controls lysosome biogenesis in the cell cycle. CDK4/6 inhibitors promote autophagy and lysosome-dependent degradation, which has important implications for the therapy of cancer and lysosome-related disorders.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12782
专题	科研部门_学习记忆的分子神经机制（徐林）
推荐引用方式 GB/T 7714	Yin, Qiuyuan,Jian, Youli,Xu, Meng,et al. CDK4/6 regulate lysosome biogenesis through TFEB/TFE3[J]. JOURNAL OF CELL BIOLOGY,2020,219(8).
APA	Yin, Qiuyuan.,Jian, Youli.,Xu, Meng.,Huang, Xiahe.,Wang, Niya.,...&Yang, Chonglin.(2020).CDK4/6 regulate lysosome biogenesis through TFEB/TFE3.JOURNAL OF CELL BIOLOGY,219(8).
MLA	Yin, Qiuyuan,et al."CDK4/6 regulate lysosome biogenesis through TFEB/TFE3".JOURNAL OF CELL BIOLOGY 219.8(2020).

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