Spaced Training Enhances Contextual Fear Memory via Activating Hippocampal 5-HT2A Receptors

	Spaced Training Enhances Contextual Fear Memory via Activating Hippocampal 5-HT2A Receptors
	Jiang, Lizhu; Wang, Liping; Yin, Yan; Huo, Mengke; Liu, Chao; Zhou, Qixin; Yu, Dafu; Xu, Lin; Mao, Rongrong
	2020
发表期刊	FRONTIERS IN MOLECULAR NEUROSCIENCE
ISSN	1662-5099
卷号	12
摘要	Spaced training is robustly superior to massed training, which is a well-documented phenomenon in humans and animals. However, the mechanisms underlying the spacing effect still remain unclear. We have reported previously that spacing training exerts memory-enhancing effects by inhibiting forgetting via decreasing hippocampal Rac1 activity. Here, using contextual fear conditioning in rat, we found that spaced but not massed training increased hippocampal 5-HT2A receptors' expression. Furthermore, hippocampal administration of 5-HT2A receptor antagonist MDL11939 before spaced training blocked the enhanced memory, while hippocampal administration of 5-HT2A receptor agonist TCB-2 before massed training promoted the memory. Moreover, MDL11939 activated hippocampal Rac1, while TCB-2 decreased hippocampal Rac1 activity in naive rats. These results indicated the possibility of interaction between 5-HT2A receptors and Rac1, which was demonstrated by co-immunoprecipitation experiments. Our study first demonstrates that activation of hippocampal 5-HT2A is a mechanism underlying the spacing effect, and forgetting related molecular Rac1 is engaged in this process through interacting with 5-HT2A receptors, which suggest a promising strategy to modulate abnormal learning in cognitive disorders.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12783
专题	科研部门_学习记忆的分子神经机制（徐林）
推荐引用方式 GB/T 7714	Jiang, Lizhu,Wang, Liping,Yin, Yan,et al. Spaced Training Enhances Contextual Fear Memory via Activating Hippocampal 5-HT2A Receptors[J]. FRONTIERS IN MOLECULAR NEUROSCIENCE,2020,12.
APA	Jiang, Lizhu.,Wang, Liping.,Yin, Yan.,Huo, Mengke.,Liu, Chao.,...&Mao, Rongrong.(2020).Spaced Training Enhances Contextual Fear Memory via Activating Hippocampal 5-HT2A Receptors.FRONTIERS IN MOLECULAR NEUROSCIENCE,12.
MLA	Jiang, Lizhu,et al."Spaced Training Enhances Contextual Fear Memory via Activating Hippocampal 5-HT2A Receptors".FRONTIERS IN MOLECULAR NEUROSCIENCE 12(2020).

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