Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation

KIZ OpenIR > 科研部门 > 比较基因组学（宿兵）

	Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
	Xin, Jingxue; Zhang, Hui; He, Yaoxi; Duren, Zhana; Bai, Caijuan; Chen, Lang; Luo, Xin; Yan, Dong-Sheng; Zhang, Chaoyu; Zhu, Xiang; Yuan, Qiuyue; Feng, Zhanying; Cui, Chaoying; Qi, Xuebin; Ouzhuluobu; Wong, Wing Hung; Wang, Yong; Su, Bing
	2020
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	11 期号:1
摘要	High-altitude adaptation of Tibetans represents a remarkable case of natural selection during recent human evolution. Previous genome-wide scans found many non-coding variants under selection, suggesting a pressing need to understand the functional role of non-coding regulatory elements (REs). Here, we generate time courses of paired ATAC-seq and RNA-seq data on cultured HUVECs under hypoxic and normoxic conditions. We further develop a variant interpretation methodology (vPECA) to identify active selected REs (ASREs) and associated regulatory network. We discover three causal SNPs of EPAS1, the key adaptive gene for Tibetans. These SNPs decrease the accessibility of ASREs with weakened binding strength of relevant TFs, and cooperatively down-regulate EPAS1 expression. We further construct the downstream network of EPAS1, elucidating its roles in hypoxic response and angiogenesis. Collectively, we provide a systematic approach to interpret phenotype-associated noncoding variants in proper cell types and relevant dynamic conditions, to model their impact on gene regulation. Tibetan adaptation to the high-altitude environment represents a case of natural selection during recent human evolution. Here the authors investigated the chromatin and transcriptional landscape of umbilical endothelial cells from Tibetan and Han Chinese donors and provide genome-wide characterization of the hypoxia regulatory network associated high-altitude adaptation.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12789
专题	科研部门_比较基因组学（宿兵）
推荐引用方式 GB/T 7714	Xin, Jingxue,Zhang, Hui,He, Yaoxi,et al. Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation[J]. NATURE COMMUNICATIONS,2020,11(1).
APA	Xin, Jingxue.,Zhang, Hui.,He, Yaoxi.,Duren, Zhana.,Bai, Caijuan.,...&Su, Bing.(2020).Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation.NATURE COMMUNICATIONS,11(1).
MLA	Xin, Jingxue,et al."Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation".NATURE COMMUNICATIONS 11.1(2020).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2021110303.pdf（2561KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文