| EphA7 is required for otic epithelial homeostasis by modulating Claudin6 in Xenopus | |
Wang, Xiaolei; Sun, Jian; Wang, Zhaobao; Li, Chaocui; Mao, Bingyu
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| 2020 | |
| 发表期刊 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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| ISSN | 0006-291X |
| 卷号 | 526期号:2页码:375-380 |
| 摘要 | Receptor tyrosine kinase EphA7 is specifically expressed in otic region in Xenopus early development. However, its role in otocyst development remains unknown. Knockdown of EphA7 by a specific morpholino oligonucleotide (MO) reduced the size of the otocyst and triggered otic epithelial cell extrusion. Interestingly, EphA7 depletion attenuated the membrane level of the tight junction protein Claudin6 (CLDN6). Utilizing the Cldn6 MO, we further confirmed that CLDN6 attenuation also led to otic epithelial cell extrusion. Our work suggested that EphA7 modulates the otic epithelial homeostasis through stabilizing the CLDN6 membrane level. (C) 2020 Elsevier Inc. All rights reserved. |
| 收录类别 | sci |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/12841 |
| 专题 | 科研部门_发育生物学（毛炳宇） |
| 推荐引用方式 GB/T 7714 | Wang, Xiaolei,Sun, Jian,Wang, Zhaobao,et al. EphA7 is required for otic epithelial homeostasis by modulating Claudin6 in Xenopus[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2020,526(2):375-380. |
| APA | Wang, Xiaolei,Sun, Jian,Wang, Zhaobao,Li, Chaocui,&Mao, Bingyu.(2020).EphA7 is required for otic epithelial homeostasis by modulating Claudin6 in Xenopus.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,526(2),375-380. |
| MLA | Wang, Xiaolei,et al."EphA7 is required for otic epithelial homeostasis by modulating Claudin6 in Xenopus".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 526.2(2020):375-380. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2021110102.pdf（1897KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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