Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development

KIZ OpenIR > 科研部门 > 发育生物学（毛炳宇）

	Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development
	Song, Ning-Ning; Ma, Pengcheng; Zhang, Qiong; Zhang, Lei; Wang, Huishan; Zhang, Longlong; Zhu, Liang; He, Chun-Hui; Mao, Bingyu; Ding, Yu-Qiang
	2020
发表期刊	DEVELOPMENT
ISSN	0950-1991
卷号	147 期号:6
摘要	Noradrenaline belongs to the monoamine system and is involved in cognition and emotional behaviors. Phox2a and Phox2b play essential but non-redundant roles during development of the locus coeruleus (LC), the main noradrenergic (NA) neuron center in the mammalian brain. The ubiquitin E3 ligase Rnf220 and its cofactor Zc4h2 participate in ventral neural tube patterning by modulating Shh/Gli signaling, and ZC4H2 mutation is associated with intellectual disability, although the mechanisms for this remain poorly understood. Here, we report that Zc4h2 and Rnf220 are required for the development of central NA neurons in the mouse brain. Both Zc4h2 and Rnf220 are expressed in developing LC-NA neurons. Although properly initiated at E10.5, the expression of genes associated with LC-NA neurons is not maintained at the later embryonic stages in mice with a deficiency of either Rnf220 or Zc4h2. In addition, we show that the Rnf220/Zc4h2 complex monoubiquitylates Phox2a/Phox2b, a process required for the full transcriptional activity of Phox2a/Phox2b. Our work reveals a role for Rnf220/Zc4h2 in regulating LC-NA neuron development, and this finding may be helpful for understanding the pathogenesis of ZC4H2 mutation-associated intellectual disability.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12842
专题	科研部门_发育生物学（毛炳宇）
推荐引用方式 GB/T 7714	Song, Ning-Ning,Ma, Pengcheng,Zhang, Qiong,et al. Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development[J]. DEVELOPMENT,2020,147(6).
APA	Song, Ning-Ning.,Ma, Pengcheng.,Zhang, Qiong.,Zhang, Lei.,Wang, Huishan.,...&Ding, Yu-Qiang.(2020).Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development.DEVELOPMENT,147(6).
MLA	Song, Ning-Ning,et al."Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development".DEVELOPMENT 147.6(2020).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2021110103.pdf（13904KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文