ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling

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	ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling
	Ma, Pengcheng; Song, Ning-Ning; Cheng, Xiaoning; Zhu, Liang; Zhang, Qiong; Zhang, Long long; Yang, Xiangcai; Wang, Huishan; Kong, Qinghua; Shi, Deli; Ding, Yu-Qiang; Mao, Bingyu
	2020
发表期刊	JOURNAL OF MOLECULAR CELL BIOLOGY
ISSN	1674-2788
卷号	12 期号:5 页码:337-344
摘要	ZC4H2 encodes a C4H2 type zinc-finger nuclear factor, the mutation of which has been associated with disorders with various clinical phenotypes in human, including developmental delay, intellectual disability and dystonia. ZC4H2 has been suggested to regulate spinal cord patterning in zebrafish as a co-factor for RNF220, an ubiquitin E3 ligase involved in Gli signaling. Here we showed that ZC4H2 and RNF220 knockout animals phenocopy each other in spinal patterning in both mouse and zebrafish, with mispatterned progenitor and neuronal domains in the ventral spinal cord. We showed evidence that ZC4H2 is required for the stability of RNF220 and also proper Gli ubiquitination and signaling in vivo. Our data providesnew insights into the possible etiology of the neurodevelopmental impairments observed in ZC4H2-associated syndromes.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12843
专题	科研部门_发育生物学（毛炳宇）
推荐引用方式 GB/T 7714	Ma, Pengcheng,Song, Ning-Ning,Cheng, Xiaoning,et al. ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2020,12(5):337-344.
APA	Ma, Pengcheng.,Song, Ning-Ning.,Cheng, Xiaoning.,Zhu, Liang.,Zhang, Qiong.,...&Mao, Bingyu.(2020).ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling.JOURNAL OF MOLECULAR CELL BIOLOGY,12(5),337-344.
MLA	Ma, Pengcheng,et al."ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling".JOURNAL OF MOLECULAR CELL BIOLOGY 12.5(2020):337-344.

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