Mifepristone Derivative FZU-00,003 Suppresses Triple-negative Breast Cancer Cell Growth partially via miR-153-KLF5 axis

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	Mifepristone Derivative FZU-00,003 Suppresses Triple-negative Breast Cancer Cell Growth partially via miR-153-KLF5 axis
	Liu, Rong; Chen, Haijun; Zhao, Ping; Chen, Chuan-Huizi; Liang, Huichun; Yang, Chuanyu; Zhou, Zhongmei; Zhi, Xu; Liu, Suling; Chen, Ceshi
	2020
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN	1449-2288
卷号	16 期号:4 页码:611-619
摘要	Triple-negative breast cancer (TNBC) is one of the most malignant breast cancers lacking targeted therapeutics currently. We recently reported that mifepristone (MIF), a drug regularly used for abortion, suppresses TNBC cell growth by inhibiting KLF5 expression via inducing miR-153. However, its anticancer efficacy is only modest at high dose. In order to enhance the anticancer activities, a focused compound library containing 17 compounds by altering the sensitive metabolic region of mifepristone has been designed and synthesized. We first tested the cell growth inhibitory effects of these compounds in TNBC cell lines. Among them, FZU-00,003 displayed the most potent efficiency. FZU-00,003 suppresses TNBC cell growth, cell cycle progression and induces apoptosis more effectively than MIF does. Consistently, FZU-00,003 induces miR-153 expression and suppressed KLF5 expression at much lower dosages than MIF does. Furthermore, FZU-00,003 inhibits tumor growth more potently than MIF does. Taken together, the MIF derivative, FZU-00,003 may serve as a better therapeutic compound for TNBC than MIF.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12875
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Liu, Rong,Chen, Haijun,Zhao, Ping,et al. Mifepristone Derivative FZU-00,003 Suppresses Triple-negative Breast Cancer Cell Growth partially via miR-153-KLF5 axis[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2020,16(4):611-619.
APA	Liu, Rong.,Chen, Haijun.,Zhao, Ping.,Chen, Chuan-Huizi.,Liang, Huichun.,...&Chen, Ceshi.(2020).Mifepristone Derivative FZU-00,003 Suppresses Triple-negative Breast Cancer Cell Growth partially via miR-153-KLF5 axis.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,16(4),611-619.
MLA	Liu, Rong,et al."Mifepristone Derivative FZU-00,003 Suppresses Triple-negative Breast Cancer Cell Growth partially via miR-153-KLF5 axis".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 16.4(2020):611-619.

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