Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy

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	Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy
	Zhang, Rou; Liu, Wenjin; Sun, Jian; Kong, Yanjie; Chen, Ceshi
	2020
发表期刊	PHARMACOLOGICAL RESEARCH
ISSN	1043-6618
卷号	155
摘要	The dysfunction of E3 ubiquitin ligases is important in the pathogenesis of many human diseases, as they play important roles in multiple cellular processes. In this review, we evaluated the structures, functions and clinical significance of two RING-type E3 ubiquitin ligases from the same subfamily, ring-finger protein 126 (RNF126) and breast cancer associated gene 2 (BCA2). Interestingly, the expression of RNF126 and BCA2 are regulated by multiple signaling pathways, including EGFR, ERK, AKT, and NF-kappa B. RNF126 and BCA2 appear to be functional mediators for not only DNA damage repair but also cancer development. Due to their significant functions in cell proliferation and DNA damage repair, RNF126 and BCA2 may be two potential diagnostic biomarkers and therapeutic targets for cancers.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12876
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Zhang, Rou,Liu, Wenjin,Sun, Jian,et al. Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy[J]. PHARMACOLOGICAL RESEARCH,2020,155.
APA	Zhang, Rou,Liu, Wenjin,Sun, Jian,Kong, Yanjie,&Chen, Ceshi.(2020).Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy.PHARMACOLOGICAL RESEARCH,155.
MLA	Zhang, Rou,et al."Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy".PHARMACOLOGICAL RESEARCH 155(2020).

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