TNF-alpha increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-kappa B pathway

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	TNF-alpha increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-kappa B pathway
	Liu, Wenjing; Lu, Xiaoqing; Shi, Peiguo; Yang, Guangxi; Zhou, Zhongmei; Li, Wei; Mao, Xiaoyun; Jiang, Dewei; Chen, Ceshi
	2020
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	10 期号:1
摘要	Breast cancer patients often suffer from disease relapse and metastasis due to the presence of breast cancer stem-like cells (BCSCs). Numerous studies have reported that high levels of inflammatory factors, including tumor necrosis factor alpha (TNF-alpha), promote BCSCs. However, the mechanism by which TNF-alpha promotes BCSCs is unclear. In this study, we demonstrate that TNF-alpha up-regulates TAZ, a transcriptional co-activator promoting BCSC self-renewal capacity in human breast cancer cell lines. Depletion of TAZ abrogated the increase in BCSCs mediated by TNF-alpha. TAZ is induced by TNF-alpha through the non-canonical NF-kappa B pathway, and our findings suggest that TAZ plays a crucial role in inflammatory factor-promoted breast cancer stemness and could serve as a promising therapeutic target.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12878
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Liu, Wenjing,Lu, Xiaoqing,Shi, Peiguo,et al. TNF-alpha increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-kappa B pathway[J]. SCIENTIFIC REPORTS,2020,10(1).
APA	Liu, Wenjing.,Lu, Xiaoqing.,Shi, Peiguo.,Yang, Guangxi.,Zhou, Zhongmei.,...&Chen, Ceshi.(2020).TNF-alpha increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-kappa B pathway.SCIENTIFIC REPORTS,10(1).
MLA	Liu, Wenjing,et al."TNF-alpha increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-kappa B pathway".SCIENTIFIC REPORTS 10.1(2020).

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