Pyrrolo [3,4-b]-quinolin-9-amine compound FZU-0038-056 suppresses triple-negative breast cancer partially through inhibiting the expression of Bcl-2

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Pyrrolo [3,4-b]-quinolin-9-amine compound FZU-0038-056 suppresses triple-negative breast cancer partially through inhibiting the expression of Bcl-2
	Wang, Danping; Nie, Zhi; Jiang, Xiaoyan; Ye, Jinxiang; Wei, Zhimin; Cheng, Dating; Wang, Chenyang; Wu, Yingying; Liu, Rong; Chen, Haijun; Chen, Ceshi; Wang, Chunyan
	2020
发表期刊	AGING-US
ISSN	1945-4589
卷号	12 期号:10 页码:9621-9632
摘要	Triple-negative breast cancer (TNBC) has a poorer prognosis than other subtypes of breast cancer; however, it lacks effective targeted therapies clinically. In this study, we found FZU-0038-056, a novel compound derived from last-stage functionalization of tetrahydro-beta-carboline scaffold, showed the most potent anti-cancer activity against TNBC cells among the 42 synthesized derivatives. We found FZU-0038-056 significantly induces apoptosis in HCC1806 and HCC1937 TNBC cells. FZU-0038-056 reduces the expression levels of several anti-apoptosis proteins, including Bcl-2, Mcl-1 and XIAP. Furthermore, we found FZU-0038-056 induces apoptosis partially through inhibiting the expression of Bcl-2. Finally, we found FZU-0038-056 significantly suppresses HCC1806 xenograft tumor growth in nude mice without affecting their body weight. Therefore, FZU-0038-056 has the potential to be a new anticancer agent for treating human TNBC.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12880
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Wang, Danping,Nie, Zhi,Jiang, Xiaoyan,et al. Pyrrolo [3,4-b]-quinolin-9-amine compound FZU-0038-056 suppresses triple-negative breast cancer partially through inhibiting the expression of Bcl-2[J]. AGING-US,2020,12(10):9621-9632.
APA	Wang, Danping.,Nie, Zhi.,Jiang, Xiaoyan.,Ye, Jinxiang.,Wei, Zhimin.,...&Wang, Chunyan.(2020).Pyrrolo [3,4-b]-quinolin-9-amine compound FZU-0038-056 suppresses triple-negative breast cancer partially through inhibiting the expression of Bcl-2.AGING-US,12(10),9621-9632.
MLA	Wang, Danping,et al."Pyrrolo [3,4-b]-quinolin-9-amine compound FZU-0038-056 suppresses triple-negative breast cancer partially through inhibiting the expression of Bcl-2".AGING-US 12.10(2020):9621-9632.

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