A new Schiff base copper(II) complex induces cancer cell growth inhibition and apoptosis by multiple mechanisms

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	A new Schiff base copper(II) complex induces cancer cell growth inhibition and apoptosis by multiple mechanisms
	Bao, Rui-Dan; Song, Xue-Qing; Kong, Yan-jie; Li, Fang-Fang; Liao, Wen-Hui; Zhou, Jie; Zhang, Ji-hong; Zhao, Qi-Hua; Xu, Jing-Yuan; Chen, Ce-shi; Xie, Ming-Jin
	2020
发表期刊	JOURNAL OF INORGANIC BIOCHEMISTRY
ISSN	0162-0134
卷号	208
摘要	A new Schiff base copper(II) complex [N,N'-bis(2'-hydroxyphenylacetone)-o-ethanediamine] copper (II) (M1) has been synthesized and characterized by single X-ray crystallography. The cytotoxicity of complex M1 was evaluated against HeLa, LoVo, A549, A549/cis cancer cell lines, and the normal cell lines LO2 and HUVEC, by MTT (3-(4,5-dimethylthiazoyl-2-yl)2,5-diphenyltetrazoliumbromide) assays. The IC50 (50% inhibition concentrations) is in the range of 5.13-11.68 mu M, which is somewhat lower than cisplatin on the basis of platinum molar concentration. Furthermore, anticancer mechanistic studies showed that the complex M1 inhibited cell proliferation by blocking DNA synthesis and then acted on nuclear division of HeLa cells over time. Moreover, M1 increased intracellular ROS (Reactive oxygen species) levels in a dose-dependent manner. Western blot analysis indicated M1 dramatically decrease c-Myc transcription factor and KLF5 (Kruppel-like factor 5) protein expression levels in HeLa. M1 did not inhibit proteasomal activity. Finally, M1 induced DNA damages and activated the DNA damage repair pathways.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12883
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Bao, Rui-Dan,Song, Xue-Qing,Kong, Yan-jie,et al. A new Schiff base copper(II) complex induces cancer cell growth inhibition and apoptosis by multiple mechanisms[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2020,208.
APA	Bao, Rui-Dan.,Song, Xue-Qing.,Kong, Yan-jie.,Li, Fang-Fang.,Liao, Wen-Hui.,...&Xie, Ming-Jin.(2020).A new Schiff base copper(II) complex induces cancer cell growth inhibition and apoptosis by multiple mechanisms.JOURNAL OF INORGANIC BIOCHEMISTRY,208.
MLA	Bao, Rui-Dan,et al."A new Schiff base copper(II) complex induces cancer cell growth inhibition and apoptosis by multiple mechanisms".JOURNAL OF INORGANIC BIOCHEMISTRY 208(2020).

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