Econazole nitrate reversed the resistance of breast cancer cells to Adriamycin through inhibiting the PI3K/AKT signaling pathway

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Econazole nitrate reversed the resistance of breast cancer cells to Adriamycin through inhibiting the PI3K/AKT signaling pathway
	Dong, Chao; Chen, Yin; Ma, Jing; Yang, Runxiang; Li, Hongjian; Liu, Rong; You, Dingyun; Luo, Chunxiang; Li, Heng; Yang, Siyuan; Ke, Kunbin; Lin, Marie Chia-mi; Chen, Ceshi
	2020
发表期刊	AMERICAN JOURNAL OF CANCER RESEARCH
ISSN	2156-6976
卷号	10 期号:1 页码:263-274
摘要	Activation of the phosphoinositide 3 kinase (PI3K)/AKT pathway is frequently implicated in resistance to anti cancer therapies. PI3K inhibitors can restore sensitivity to standard breast cancer therapies, including endocrine therapy, HER2-targeted agents, and chemotherapy. Our previous research showed that econazole, a novel PI3Ka Inhibitor, inhibits the PI3K/AKT pathway and induces apoptosis in lung cancer cells. In this study, econazole showed significant cytotoxic activity against Adriamycin-resistant breast cancer cells in vitro and in vivo. Additionally, econazole significantly sensitized MDA-MB-231 and MCF-7 cells to Adriamycin via inhibiting the PI3K/AKT pathway. Overexpression of constitutively active AKT1 abolished the function of econazole. The combination of econazole and Adriamycin exerted synergistic inhibitory effects in breast cancer cells in vitro and in vivo. Taken together, the PI3K inhibitor econazole could effectively overcome Adriamycin resistance and showed synergistic effects with chemotherapy on breast cancer.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12884
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Dong, Chao,Chen, Yin,Ma, Jing,et al. Econazole nitrate reversed the resistance of breast cancer cells to Adriamycin through inhibiting the PI3K/AKT signaling pathway[J]. AMERICAN JOURNAL OF CANCER RESEARCH,2020,10(1):263-274.
APA	Dong, Chao.,Chen, Yin.,Ma, Jing.,Yang, Runxiang.,Li, Hongjian.,...&Chen, Ceshi.(2020).Econazole nitrate reversed the resistance of breast cancer cells to Adriamycin through inhibiting the PI3K/AKT signaling pathway.AMERICAN JOURNAL OF CANCER RESEARCH,10(1),263-274.
MLA	Dong, Chao,et al."Econazole nitrate reversed the resistance of breast cancer cells to Adriamycin through inhibiting the PI3K/AKT signaling pathway".AMERICAN JOURNAL OF CANCER RESEARCH 10.1(2020):263-274.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2021110111.pdf（2643KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文