Cancer progression is mediated by proline catabolism in non-small cell lung cancer

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Cancer progression is mediated by proline catabolism in non-small cell lung cancer
	Liu, Yating; Mao, Chao; Wang, Min; Liu, Na; Ouyang, Lianlian; Liu, Shouping; Tang, Haosheng; Cao, Ya; Liu, Shuang; Wang, Xiang; Xiao, Desheng; Chen, Ceshi; Shi, Ying; Yan, Qin; Tao, Yongguang
	2020
发表期刊	ONCOGENE
ISSN	0950-9232
卷号	39 期号:11 页码:2358-2376
摘要	Dysregulated metabolism contributes to cancer initiation and progression, but the key drivers of these pathways are just being discovered. Here, we report a critical role for proline catabolism in non-small cell lung cancer (NSCLC). Proline dehydrogenase (PRODH) is activated to reduce proline levels by the chromatin remodeling factor lymphoid-specific helicase (LSH), an epigenetic driver of NSCLC. PRODH promotes NSCLC tumorigenesis by inducing epithelial to mesenchymal transition (EMT) and IKK alpha-dependent inflammatory genes, including CXCL1, LCN2, and IL17C. Consistently, proline addition promotes the expression of these inflammatory genes, as well as EMT, tumor cell proliferation, and migration in vitro and tumor growth in vivo, while the depletion or inhibition of PRODH blocks these phenotypes. In summary, we reveal an essential metabolic pathway amenable to targeting in NSCLC.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12886
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Liu, Yating,Mao, Chao,Wang, Min,et al. Cancer progression is mediated by proline catabolism in non-small cell lung cancer[J]. ONCOGENE,2020,39(11):2358-2376.
APA	Liu, Yating.,Mao, Chao.,Wang, Min.,Liu, Na.,Ouyang, Lianlian.,...&Tao, Yongguang.(2020).Cancer progression is mediated by proline catabolism in non-small cell lung cancer.ONCOGENE,39(11),2358-2376.
MLA	Liu, Yating,et al."Cancer progression is mediated by proline catabolism in non-small cell lung cancer".ONCOGENE 39.11(2020):2358-2376.

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