Intracerebroventricular Administration of Interferon-Alpha Induced Depressive-Like Behaviors and Neurotransmitter Changes in Rhesus Monkeys

	Intracerebroventricular Administration of Interferon-Alpha Induced Depressive-Like Behaviors and Neurotransmitter Changes in Rhesus Monkeys
	Li, Zhifei; Li, Zhaoxia; Lv, Xiaoman; Li, Zhaofu; Xiong, Lei; Hu, Xintian; Qin, Dongdong
	2020
发表期刊	FRONTIERS IN NEUROSCIENCE
卷号	14
摘要	Interferon-alpha (IFN-alpha) is a cytokine widely used in the treatment of brain cancers and virus infections with side effects including causing depression. Monoamine neurotransmitter systems have been found playing important roles in peripheral IFN-alpha-induced depression, but how peripheral IFN-alpha accesses the central nervous system and contributes to the development of depression is poorly known. This study aimed to develop a non-human primate model using long-term intracerebroventricular (i.c.v.) administration of IFN-alpha (5 days/week for 6 weeks), to observe the induced depressive-like behaviors and to explore the contributions of monoamine neurotransmitter systems in the development of depression. In monkeys receiving i.c.v. IFN-alpha administration, anhedonia was observed as decreases of sucrose consumption, along with depressive-like symptoms including increased huddling behavior, decreases of spontaneous and reactive locomotion in home cage, as well as reduced exploration and increased motionless in the open field. Chronic central IFN-alpha infusion significantly increased the cerebrospinal fluid (CSF) concentrations of noradrenaline (NA), and 3,4-dihydroxyphenylacetic acid (DOPAC), but not 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA). These CSF monoamine metabolites showed associations with some specific depression-related behaviors. In conclusion, central IFN-alpha administration induced anhedonia and depression-related behaviors comparable to the results with peripheral administration, and the development of depression was associated with the dysfunction of monoamine neurotransmitters.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12887
专题	科研部门_神经系统编码（胡新天）
推荐引用方式 GB/T 7714	Li, Zhifei,Li, Zhaoxia,Lv, Xiaoman,et al. Intracerebroventricular Administration of Interferon-Alpha Induced Depressive-Like Behaviors and Neurotransmitter Changes in Rhesus Monkeys[J]. FRONTIERS IN NEUROSCIENCE,2020,14.
APA	Li, Zhifei.,Li, Zhaoxia.,Lv, Xiaoman.,Li, Zhaofu.,Xiong, Lei.,...&Qin, Dongdong.(2020).Intracerebroventricular Administration of Interferon-Alpha Induced Depressive-Like Behaviors and Neurotransmitter Changes in Rhesus Monkeys.FRONTIERS IN NEUROSCIENCE,14.
MLA	Li, Zhifei,et al."Intracerebroventricular Administration of Interferon-Alpha Induced Depressive-Like Behaviors and Neurotransmitter Changes in Rhesus Monkeys".FRONTIERS IN NEUROSCIENCE 14(2020).

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