Concurrent environmental enrichment and chronic restraint stress: Effects on innate anxiety and depressive-like behavior in male adolescent mice

	Concurrent environmental enrichment and chronic restraint stress: Effects on innate anxiety and depressive-like behavior in male adolescent mice
	Mao, Yu; Chen, Yanmei; Yang, Xiaomi; Wang, Jianhong; Ge, Longjiao; Fu, Juan; Sun, Huaying; Ma, Yuanye
	2020
发表期刊	INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
ISSN	0736-5748
卷号	80 期号:8 页码:730-736
摘要	Adolescence is a period that exhibits both vulnerability and adaptation to environmental stimulus. This study explored the co-existence effect of environmental enrichment (EE) and restraint stress (RS) on innate anxiety and depressive-like behavior in adolescent mice. Male ICR mice were treated with daily EE and RS (4 h/d or 8 h/d) for 2 or 4 weeks from early adolescence (postnatal day 30) and emotional behaviors were evaluated 24 h after the end of treatment. 4 weeks of 8 h RS treatment decreased immobility time in forced swimming test, demonstrating an antidepressant-like effect. For 2 weeks of treatment, 8 h RS significantly reduced the time spent in the lighted compartment of the light-dark box, indicating an increased anxiety level. These results show that under the present experimental design, RS treatment with different duration could have different effect on mice emotion-related behavior, but there was no interaction between EE and RS.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12888
专题	科研部门_神经系统编码（胡新天）
推荐引用方式 GB/T 7714	Mao, Yu,Chen, Yanmei,Yang, Xiaomi,et al. Concurrent environmental enrichment and chronic restraint stress: Effects on innate anxiety and depressive-like behavior in male adolescent mice[J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,2020,80(8):730-736.
APA	Mao, Yu.,Chen, Yanmei.,Yang, Xiaomi.,Wang, Jianhong.,Ge, Longjiao.,...&Ma, Yuanye.(2020).Concurrent environmental enrichment and chronic restraint stress: Effects on innate anxiety and depressive-like behavior in male adolescent mice.INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,80(8),730-736.
MLA	Mao, Yu,et al."Concurrent environmental enrichment and chronic restraint stress: Effects on innate anxiety and depressive-like behavior in male adolescent mice".INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 80.8(2020):730-736.

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