Local sympathetic innervations modulate the lung innate immune responses

	Local sympathetic innervations modulate the lung innate immune responses
	Liu, Tingting; Yang, Lu; Han, Xiangli; Ding, Xiaofan; Li, Jiali; Yang, Jing
	2020
发表期刊	SCIENCE ADVANCES
ISSN	2375-2548
卷号	6 期号:20
摘要	Local immunity of the lung needs to be under tight control. However, how efferent neural signals influence lung immunity remains incompletely understood. Here, we report the development of a modified iDISCO-based protocol, iDISCO(ace), for whole-tissue 3D assessment of neural innervations and immune reactions in intact, unsectioned lung tissues. We observed that genetic, pharmacologic, or surgical removal of local sympathetic innervations promoted LPS-elicited innate immune response in the lung. Also, sympathetic ablation enhanced IL-33-elicited type 2 innate immunity. We further show that the sympathetic neurotransmitter norepinephrine, or specific agonists of the beta 2-adrenergic receptor, can inhibit the LPS- or IL-33-elicited immune response in a cell-intrinsic manner. Moreover, genetic deletion of the beta 2-adrenergic receptor produced immunomodulatory effects similar to those observed with sympathetic ablation. Together, this study elucidates the critical function of local sympathetic innervations in negatively modulating the lung innate immune responses.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12908
专题	科研部门_表观遗传与神经退行性疾病（李家立）
推荐引用方式 GB/T 7714	Liu, Tingting,Yang, Lu,Han, Xiangli,et al. Local sympathetic innervations modulate the lung innate immune responses[J]. SCIENCE ADVANCES,2020,6(20).
APA	Liu, Tingting,Yang, Lu,Han, Xiangli,Ding, Xiaofan,Li, Jiali,&Yang, Jing.(2020).Local sympathetic innervations modulate the lung innate immune responses.SCIENCE ADVANCES,6(20).
MLA	Liu, Tingting,et al."Local sympathetic innervations modulate the lung innate immune responses".SCIENCE ADVANCES 6.20(2020).

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