CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis

	CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis
	Xu, Kaiyu; Zhang, Ying; Xiong, Wandi; Zhang, Zhongyu; Wang, Zhengbo; Lv, Longbao; Liu, Chao; Hu, Zhengfei; Zheng, Yong-Tang; Lu, Lin; Hu, Xin-Tian; Li, Jiali
	2020
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	11 期号:1
摘要	Circular RNAs (circRNAs) are abundant in mammalian brain and some show age-dependent expression patterns. Here, we report that circGRIA1, a conserved circRNA isoform derived from the genomic loci of alpha-mino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit Gria1, shows an age-related and male-specific increase in expression in the rhesus macaque prefrontal cortex and hippocampus. We show circGRIA1 is predominantly localized to the nucleus, and find an age-related increase in its association with the promoter region of Gria1 gene, suggesting it has a regulatory role in Gria1 transcription. In vitro and in vivo manipulation of circGRIA1 negatively regulates Gria1 mRNA and protein levels. Knockdown of circGRIA1 results in an age-related improvement of synaptogenesis, and GluR1 activity-dependent synaptic plasticity in the hippocampal neurons in males. Our findings underscore the importance of circRNA regulation and offer an insight into the biology of brain aging.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12910
专题	科研部门_表观遗传与神经退行性疾病（李家立）
推荐引用方式 GB/T 7714	Xu, Kaiyu,Zhang, Ying,Xiong, Wandi,et al. CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis[J]. NATURE COMMUNICATIONS,2020,11(1).
APA	Xu, Kaiyu.,Zhang, Ying.,Xiong, Wandi.,Zhang, Zhongyu.,Wang, Zhengbo.,...&Li, Jiali.(2020).CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis.NATURE COMMUNICATIONS,11(1).
MLA	Xu, Kaiyu,et al."CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis".NATURE COMMUNICATIONS 11.1(2020).

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