Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data

KIZ OpenIR > 科研部门 > 转化基因组（李明）

	Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data
	Li, Hui-Juan; Qu, Na; Hui, Li; Cai, Xin; Zhang, Chu-Yi; Zhong, Bao-Liang; Zhang, Shu-Fang; Chen, Jing; Xia, Bin; Wang, Lu; Jia, Qiu-Fang; Li, Wei; Chang, Hong; Xiao, Xiao; Li, Ming; Li, Yi
	2020
发表期刊	TRANSLATIONAL PSYCHIATRY
ISSN	2158-3188
卷号	10 期号:1
摘要	Genome-wide association studies (GWAS) of major depression and its relevant biological phenotypes have been extensively conducted in large samples, and transcriptome-wide analyses in the tissues of brain regions relevant to pathogenesis of depression, e.g., dorsolateral prefrontal cortex (DLPFC), have also been widely performed recently. Integrating these multi-omics data will enable unveiling of depression risk genes and even underlying pathological mechanisms. Here, we employ summary data-based Mendelian randomization (SMR) and integrative risk gene selector (iRIGS) approaches to integrate multi-omics data from GWAS, DLPFC expression quantitative trait loci (eQTL) analyses and enhancer-promoter physical link studies to prioritize high-confidence risk genes for depression, followed by independent replications across distinct populations. These integrative analyses identify multiple high-confidence depression risk genes, and numerous lines of evidence supporting pivotal roles of the netrin 1 receptor (DCC) gene in this illness across different populations. Our subsequent explorative analyses further suggest that DCC significantly predicts neuroticism, well-being spectrum, cognitive function and putamen structure in general populations. Gene expression correlation and pathway analyses in DLPFC further show that DCC potentially participates in the biological processes and pathways underlying synaptic plasticity, axon guidance, circadian entrainment, as well as learning and long-term potentiation. These results are in agreement with the recent findings of this gene in neurodevelopment and psychiatric disorders, and we thus further confirm that DCC is an important susceptibility gene for depression, and might be a potential target for new antidepressants.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12916
专题	科研部门_转化基因组（李明）
推荐引用方式 GB/T 7714	Li, Hui-Juan,Qu, Na,Hui, Li,et al. Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data[J]. TRANSLATIONAL PSYCHIATRY,2020,10(1).
APA	Li, Hui-Juan.,Qu, Na.,Hui, Li.,Cai, Xin.,Zhang, Chu-Yi.,...&Li, Yi.(2020).Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data.TRANSLATIONAL PSYCHIATRY,10(1).
MLA	Li, Hui-Juan,et al."Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data".TRANSLATIONAL PSYCHIATRY 10.1(2020).

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