Independent replications and integrative analyses confirmTRANK1as a susceptibility gene for bipolar disorder

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	Independent replications and integrative analyses confirmTRANK1as a susceptibility gene for bipolar disorder
	Li, Wenqiang; Cai, Xin; Li, Hui-Juan; Song, Meng; Zhang, Chu-Yi; Yang, Yongfeng; Zhang, Luwen; Zhao, Lijuan; Liu, Weipeng; Wang, Lu; Shao, Minglong; Zhang, Yan; Zhang, Chen; Cai, Jun; Zhou, Dong-Sheng; Li, Xingxing; Hui, Li; Jia, Qiu-Fang; Qu, Na; Zhong, Bao-Liang; Zhang, Shu-Fang; Chen, Jing; Xia, Bin; Li, Yi; Song, Xueqin; Fan, Weixing; Tang, Wei; Tang, Wenxin; Tang, Jinsong; Chen, Xiaogang; Yue, Weihua; Zhang, Dai; Fang, Yiru; Xiao, Xiao; Li, Ming; Lv, Luxian; Chang, Hong
	2021
发表期刊	NEUROPSYCHOPHARMACOLOGY
ISSN	0893-133X
卷号	46 期号:6 页码:1103-1112
摘要	Genetic analyses for bipolar disorder (BD) have achieved prominent success in Europeans in recent years, whereas its genetic basis in other populations remains relatively less understood. We herein report that the leading risk locus for BD in European genome-wide association studies (GWAS), the single-nucleotide polymorphism (SNP) rs9834970 nearTRANK1at 3p22 region, is also genome-wide significantly associated with BD in a meta-analysis of four independent East Asian samples including 5748 cases and 65,361 controls (p = 2.27 x 10(-8), odds ratio = 1.136). Expression quantitative trait loci (eQTL) analyses and summary data-based Mendelian randomization (SMR) analyses in multiple human brain samples suggest that lowerTRANK1mRNA expression is a principal BD risk factor explaining its genetic risk signals at 3p22. We also identified another SNP rs4789 in the 3 ' untranslated region (3 ' UTR) ofTRANK1showing stronger eQTL associations as well as genome-wide significant association with BD. Despite the relatively unclear neuronal function ofTRANK1, our mRNA expression analyses in the human brains and in rat primary cortical neurons reveal that genes highly correlated withTRANK1are significantly enriched in the biological processes related to dendritic spine, synaptic plasticity, axon guidance and circadian entrainment, and are also more likely to exhibit strong associations in psychiatric GWAS (e.g., theCACNA1Cgene). Overall, our results support thatTRANK1is a potential BD risk gene. Further studies elucidating its roles in this illness are needed.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12917
专题	科研部门_转化基因组（李明）
推荐引用方式 GB/T 7714	Li, Wenqiang,Cai, Xin,Li, Hui-Juan,et al. Independent replications and integrative analyses confirmTRANK1as a susceptibility gene for bipolar disorder[J]. NEUROPSYCHOPHARMACOLOGY,2021,46(6):1103-1112.
APA	Li, Wenqiang.,Cai, Xin.,Li, Hui-Juan.,Song, Meng.,Zhang, Chu-Yi.,...&Chang, Hong.(2021).Independent replications and integrative analyses confirmTRANK1as a susceptibility gene for bipolar disorder.NEUROPSYCHOPHARMACOLOGY,46(6),1103-1112.
MLA	Li, Wenqiang,et al."Independent replications and integrative analyses confirmTRANK1as a susceptibility gene for bipolar disorder".NEUROPSYCHOPHARMACOLOGY 46.6(2021):1103-1112.

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